Technology Process of Benzyl-(2,3,5,6,7,8-hexahydro-indolizin-6-yl)-carbamic acid benzyl ester
There total 21 articles about Benzyl-(2,3,5,6,7,8-hexahydro-indolizin-6-yl)-carbamic acid benzyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 67 percent / NaHCO3 / H2O
2: 60 percent / BH3 * THF / tetrahydrofuran / 18 h / 25 °C
3: 88 percent / pyridine
4: 83 percent / (PhO)2P(O)N3, EtO2C-N=N-CO2Et, Ph3P
5: 96 percent / nBu4NF / tetrahydrofuran
6: 1) (COCl)2, Me2SO, 2) Et3N
7: 89 percent / diethyl ether / 0.5 h / -78 °C
8: 1) (COCl)2, DMSO, 2) NEt3 / 1) CH2Cl2, -78 deg C, 2h, 2) 25 deg C, 1h
9: 78 percent / Ph3P / tetrahydrofuran / 18 h / 25 °C
10: NH4Cl / xylene / 2 h / 145 °C
With
pyridine; borane-THF; oxalyl dichloride; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; triphenylphosphine; diethylazodicarboxylate;
ammonium chloride;
In
tetrahydrofuran; diethyl ether; water; xylene;
DOI:10.1016/S0040-4039(00)97867-5
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 88 percent / pyridine
2: 83 percent / (PhO)2P(O)N3, EtO2C-N=N-CO2Et, Ph3P
3: 96 percent / nBu4NF / tetrahydrofuran
4: 1) (COCl)2, Me2SO, 2) Et3N
5: 89 percent / diethyl ether / 0.5 h / -78 °C
6: 1) (COCl)2, DMSO, 2) NEt3 / 1) CH2Cl2, -78 deg C, 2h, 2) 25 deg C, 1h
7: 78 percent / Ph3P / tetrahydrofuran / 18 h / 25 °C
8: NH4Cl / xylene / 2 h / 145 °C
With
pyridine; oxalyl dichloride; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; triphenylphosphine; diethylazodicarboxylate;
ammonium chloride;
In
tetrahydrofuran; diethyl ether; xylene;
DOI:10.1016/S0040-4039(00)97867-5
