(3aR,7aS)-2-(2-Hydroxy-phenyl)-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-4-one

Base Information

Chemical Name:(3aR,7aS)-2-(2-Hydroxy-phenyl)-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-4-one
CAS No.:1412906-17-2
Molecular Formula:C₂₁H₂₁F₃N₂O₃
Molecular Weight:406.405
Hs Code.:

Synonyms:

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Chemical Property of (3aR,7aS)-2-(2-Hydroxy-phenyl)-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-4-one

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Technology Process of (3aR,7aS)-2-(2-Hydroxy-phenyl)-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-4-one

There total 8 articles about (3aR,7aS)-2-(2-Hydroxy-phenyl)-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1412905-93-1
N-But-3-enyl-N-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-acrylamide

: 1412906-17-2
(3aR,7aS)-2-(2-Hydroxy-phenyl)-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-4-one

Guidance literature:: Multi-step reaction with 6 steps

1: Grubbs catalyst / dichloromethane / 45 °C

2: trifluoroacetic acid / dichloromethane / 30 h / 45 °C

3: hydrogen / palladium on carbon / methanol / 3 h / 20 °C

4: hydrogenchloride / ethyl acetate / 1.5 h

5: potassium tert-butylate; johnphos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / Reflux; Inert atmosphere

6: boron trifluoride / dichloromethane / 4 h / -78 - 20 °C / Reflux

With hydrogenchloride; boron trifluoride; potassium tert-butylate; hydrogen; trifluoroacetic acid; johnphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on carbon; In methanol; dichloromethane; ethyl acetate; toluene;

Reference yield:

: 1412905-95-3
2-benzyl-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-4-one

: 1412906-17-2
(3aR,7aS)-2-(2-Hydroxy-phenyl)-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium on carbon / methanol / 3 h / 20 °C

2: hydrogenchloride / ethyl acetate / 1.5 h

3: potassium tert-butylate; johnphos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / Reflux; Inert atmosphere

4: boron trifluoride / dichloromethane / 4 h / -78 - 20 °C / Reflux

With hydrogenchloride; boron trifluoride; potassium tert-butylate; hydrogen; johnphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on carbon; In methanol; dichloromethane; ethyl acetate; toluene;

Reference yield:

: 1412905-94-2
1-[4-(2,2,2-Trifluoro-ethoxy)-phenyl]-5,6-dihydro-1H-pyridin-2-one

: 1412906-17-2
(3aR,7aS)-2-(2-Hydroxy-phenyl)-5-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-octahydro-pyrrolo[3,4-c]pyridin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / dichloromethane / 30 h / 45 °C

2: hydrogen / palladium on carbon / methanol / 3 h / 20 °C

3: hydrogenchloride / ethyl acetate / 1.5 h

4: potassium tert-butylate; johnphos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / Reflux; Inert atmosphere

5: boron trifluoride / dichloromethane / 4 h / -78 - 20 °C / Reflux

With hydrogenchloride; boron trifluoride; potassium tert-butylate; hydrogen; trifluoroacetic acid; johnphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on carbon; In methanol; dichloromethane; ethyl acetate; toluene;