[(1S,3S,4R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-bicyclo[3.1.0]hex-1-yl]-carbamic acid benzyl ester

Base Information

Chemical Name:[(1S,3S,4R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-bicyclo[3.1.0]hex-1-yl]-carbamic acid benzyl ester
CAS No.:156043-97-9
Molecular Formula:C₂₇H₄₇NO₄Si₂
Molecular Weight:505.845
Hs Code.:

[(1S,3S,4R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-bicyclo[3.1.0]hex-1-yl]-carbamic acid benzyl ester

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Chemical Property of [(1S,3S,4R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-bicyclo[3.1.0]hex-1-yl]-carbamic acid benzyl ester

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Technology Process of [(1S,3S,4R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-bicyclo[3.1.0]hex-1-yl]-carbamic acid benzyl ester

There total 5 articles about [(1S,3S,4R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-bicyclo[3.1.0]hex-1-yl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 156043-96-8
(1S,3S,4R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-bicyclo[3.1.0]hexane-1-carboxylic acid

: 156043-97-9
[(1S,3S,4R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-bicyclo[3.1.0]hex-1-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DPPA, Et₃N / toluene / 1.) 0 deg C, 1 h; 2.) r.t., 1h

2: toluene / 2 h / 80 °C

3: toluene / 1.) 80 deg C, 2 h; 2.) 100 deg C, 15 min

With diphenyl-phosphinic acid; triethylamine; In toluene;
DOI:10.1016/S0040-4039(00)78359-6

Reference yield:

: 156043-95-7
(1S,3S,4R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-bicyclo[3.1.0]hexane-1-carboxylic acid methyl ester

: 156043-97-9
[(1S,3S,4R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-bicyclo[3.1.0]hex-1-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / KOH / ethanol / 5 h / 80 °C

2: DPPA, Et₃N / toluene / 1.) 0 deg C, 1 h; 2.) r.t., 1h

3: toluene / 2 h / 80 °C

4: toluene / 1.) 80 deg C, 2 h; 2.) 100 deg C, 15 min

With potassium hydroxide; diphenyl-phosphinic acid; triethylamine; In ethanol; toluene;
DOI:10.1016/S0040-4039(00)78359-6

Reference yield:

: 156043-94-6
(1R,2S,3R,4S)-2-Bromomethyl-4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-dimethyl-silanyloxymethyl)-cyclopentanecarboxylic acid methyl ester

: 156043-97-9
[(1S,3S,4R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-bicyclo[3.1.0]hex-1-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / t-BuOK / 2-methyl-propan-2-ol / 0.5 h / Ambient temperature

2: 78 percent / KOH / ethanol / 5 h / 80 °C

3: DPPA, Et₃N / toluene / 1.) 0 deg C, 1 h; 2.) r.t., 1h

4: toluene / 2 h / 80 °C

5: toluene / 1.) 80 deg C, 2 h; 2.) 100 deg C, 15 min

With potassium hydroxide; diphenyl-phosphinic acid; potassium tert-butylate; triethylamine; In ethanol; toluene; tert-butyl alcohol;
DOI:10.1016/S0040-4039(00)78359-6