Technology Process of 2-phenyl-1-azaspiro[4.5]deca-1,7-diene
There total 7 articles about 2-phenyl-1-azaspiro[4.5]deca-1,7-diene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); triethylamine; tris<3,5-bis(trifluoromethyl)phenyl>phosphane;
In
N,N-dimethyl-formamide;
at 120 ℃;
for 1.5h;
Overall yield = 84 %; Overall yield = 31.2 mg;
Inert atmosphere;
DOI:10.1039/c2cc38944d
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 16 h / 0 - 20 °C
2: tris-(dibenzylideneacetone)dipalladium(0); tris<3,5-bis(trifluoromethyl)phenyl>phosphane; triethylamine / N,N-dimethyl-formamide / 1.5 h / 120 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); triethylamine; tris<3,5-bis(trifluoromethyl)phenyl>phosphane;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c2cc38944d
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
2.1: phosphorus tribromide / diethyl ether / 16 h / 0 - 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C
3.2: 16 h / 80 °C
4.1: potassium hydroxide / tetrahydrofuran; mineral oil; methanol; water / 75 °C
5.1: hydroxylamine hydrochloride; sodium acetate / methanol / 2 h / 75 °C
6.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C
7.1: tris-(dibenzylideneacetone)dipalladium(0); tris<3,5-bis(trifluoromethyl)phenyl>phosphane; triethylamine / N,N-dimethyl-formamide / 1.5 h / 120 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); lithium aluminium tetrahydride; hydroxylamine hydrochloride; sodium acetate; phosphorus tribromide; sodium hydride; triethylamine; tris<3,5-bis(trifluoromethyl)phenyl>phosphane; potassium hydroxide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c2cc38944d