(-)-N-(2-((S)-1-allyl-3-((3aS,3'aR,8aS,8'aS)-8'-allyl-1,1'-dimethyl-2,2',3,3',8,8a,8',8'a-octahydro-1H,1'H-[3a,3'a-bipyrrolo[2,3-b]indol]-7-yl)-2-oxoindolin-3-yl)ethyl)-N,4-dimethylbenzenesulfonamide

Base Information

Chemical Name:(-)-N-(2-((S)-1-allyl-3-((3aS,3'aR,8aS,8'aS)-8'-allyl-1,1'-dimethyl-2,2',3,3',8,8a,8',8'a-octahydro-1H,1'H-[3a,3'a-bipyrrolo[2,3-b]indol]-7-yl)-2-oxoindolin-3-yl)ethyl)-N,4-dimethylbenzenesulfonamide
CAS No.:1448523-03-2
Molecular Formula:C₄₆H₅₂N₆O₃S
Molecular Weight:769.023
Hs Code.:

(-)-N-(2-((S)-1-allyl-3-((3aS,3'aR,8aS,8'aS)-8'-allyl-1,1'-dimethyl-2,2',3,3',8,8a,8',8'a-octahydro-1H,1'H-[3a,3'a-bipyrrolo[2,3-b]indol]-7-yl)-2-oxoindolin-3-yl)ethyl)-N,4-dimethylbenzenesulfonamide

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Suppliers and Price of (-)-N-(2-((S)-1-allyl-3-((3aS,3'aR,8aS,8'aS)-8'-allyl-1,1'-dimethyl-2,2',3,3',8,8a,8',8'a-octahydro-1H,1'H-[3a,3'a-bipyrrolo[2,3-b]indol]-7-yl)-2-oxoindolin-3-yl)ethyl)-N,4-dimethylbenzenesulfonamide

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Chemical Property of (-)-N-(2-((S)-1-allyl-3-((3aS,3'aR,8aS,8'aS)-8'-allyl-1,1'-dimethyl-2,2',3,3',8,8a,8',8'a-octahydro-1H,1'H-[3a,3'a-bipyrrolo[2,3-b]indol]-7-yl)-2-oxoindolin-3-yl)ethyl)-N,4-dimethylbenzenesulfonamide

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Technology Process of (-)-N-(2-((S)-1-allyl-3-((3aS,3'aR,8aS,8'aS)-8'-allyl-1,1'-dimethyl-2,2',3,3',8,8a,8',8'a-octahydro-1H,1'H-[3a,3'a-bipyrrolo[2,3-b]indol]-7-yl)-2-oxoindolin-3-yl)ethyl)-N,4-dimethylbenzenesulfonamide

There total 11 articles about (-)-N-(2-((S)-1-allyl-3-((3aS,3'aR,8aS,8'aS)-8'-allyl-1,1'-dimethyl-2,2',3,3',8,8a,8',8'a-octahydro-1H,1'H-[3a,3'a-bipyrrolo[2,3-b]indol]-7-yl)-2-oxoindolin-3-yl)ethyl)-N,4-dimethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1344977-38-3
(-)-(3aS,3'aR,8aS,8'aS)-8'-allyl-7-bromo-1,1'-dimethyl-2,2',3,3',8,8a,8',8'a-octahydro-1H,1'H-3a,3'a-bipyrrolo[2,3-b]indole

: 1448523-00-9
N-(2-(1-allyl-2-oxoindolin-3-yl)ethyl)-N,4-dimethylbenzenesulfonamide

: 1448523-03-2
(-)-N-(2-((S)-1-allyl-3-((3aS,3'aR,8aS,8'aS)-8'-allyl-1,1'-dimethyl-2,2',3,3',8,8a,8',8'a-octahydro-1H,1'H-[3a,3'a-bipyrrolo[2,3-b]indol]-7-yl)-2-oxoindolin-3-yl)ethyl)-N,4-dimethylbenzenesulfonamide

Guidance literature:: With C₁₂H₂₇Pt*(x)BF₄*H⁽¹⁺⁾; palladium diacetate; caesium carbonate; In toluene; at 100 ℃; for 2h; Inert atmosphere;
DOI:10.1002/chem.201203150

Reference yield:

: 4147-37-9
meso-Chimonanthine

: 1448523-03-2
(-)-N-(2-((S)-1-allyl-3-((3aS,3'aR,8aS,8'aS)-8'-allyl-1,1'-dimethyl-2,2',3,3',8,8a,8',8'a-octahydro-1H,1'H-[3a,3'a-bipyrrolo[2,3-b]indol]-7-yl)-2-oxoindolin-3-yl)ethyl)-N,4-dimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane; bis(η3-allyl-μ-chloropalladium(II)); potassium tert-butylate / toluene; 1,4-dioxane / 16 h / -15 - 0 °C / Inert atmosphere

2: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; ethylene dibromide / diethyl ether / 1.5 h / -78 - 0 °C / Inert atmosphere

4: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 16 h / 20 °C / Inert atmosphere

5: caesium carbonate; C₁₂H₂₇Pt*(x)BF₄*H⁽¹⁺⁾; palladium diacetate / toluene / 2 h / 100 °C / Inert atmosphere

With bis(η3-allyl-μ-chloropalladium(II)); N,N,N,N,-tetramethylethylenediamine; trimethylsilyl trifluoromethanesulfonate; C₁₂H₂₇Pt*(x)BF₄*H⁽¹⁺⁾; potassium tert-butylate; sec.-butyllithium; palladium diacetate; sodium hexamethyldisilazane; caesium carbonate; (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane; ethylene dibromide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; toluene;
DOI:10.1002/chem.201203150

Reference yield:

: 58635-45-3
methyl 2-(1-H-indol-3-yl)ethylcarbamate

: 1448523-03-2
(-)-N-(2-((S)-1-allyl-3-((3aS,3'aR,8aS,8'aS)-8'-allyl-1,1'-dimethyl-2,2',3,3',8,8a,8',8'a-octahydro-1H,1'H-[3a,3'a-bipyrrolo[2,3-b]indol]-7-yl)-2-oxoindolin-3-yl)ethyl)-N,4-dimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene / 5.5 h / -30 °C / Inert atmosphere

2: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 16 h / Inert atmosphere; Reflux

3: (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane; bis(η3-allyl-μ-chloropalladium(II)); potassium tert-butylate / toluene; 1,4-dioxane / 16 h / -15 - 0 °C / Inert atmosphere

4: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

5: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; ethylene dibromide / diethyl ether / 1.5 h / -78 - 0 °C / Inert atmosphere

6: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 16 h / 20 °C / Inert atmosphere

7: caesium carbonate; C₁₂H₂₇Pt*(x)BF₄*H⁽¹⁺⁾; palladium diacetate / toluene / 2 h / 100 °C / Inert atmosphere

With bis(η3-allyl-μ-chloropalladium(II)); N,N,N,N,-tetramethylethylenediamine; trimethylsilyl trifluoromethanesulfonate; C₁₂H₂₇Pt*(x)BF₄*H⁽¹⁺⁾; potassium tert-butylate; sec.-butyllithium; palladium diacetate; sodium hexamethyldisilazane; caesium carbonate; (1R,2R)-1,2-bis[(2-diphenylphosphanyl)benzoylamino]cyclohexane; ethylene dibromide; sodium bis(2-methoxyethoxy)aluminium dihydride; trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; toluene;
DOI:10.1002/chem.201203150