(1RS,2SR,7RS,9RS,11SR)-6-aza-11-(carbomethoxymethyl)-9-(phenylthio)-1-<(trimethylsilyl)oxy>tricyclo<5.3.1.0^2,6>undecane

Base Information

• Chemical Name: (1RS,2SR,7RS,9RS,11SR)-6-aza-11-(carbomethoxymethyl)-9-(phenylthio)-1-<(trimethylsilyl)oxy>tricyclo<5.3.1.0^2,6>undecane
• CAS No.: 94707-75-2
• Molecular Formula: C₂₂H₃₃NO₃SSi
• Molecular Weight: 419.66
• Mol file: 94707-75-2.mol

Synonyms:

Chemical Property of (1RS,2SR,7RS,9RS,11SR)-6-aza-11-(carbomethoxymethyl)-9-(phenylthio)-1-<(trimethylsilyl)oxy>tricyclo<5.3.1.0^2,6>undecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1RS,2SR,7RS,9RS,11SR)-6-aza-11-(carbomethoxymethyl)-9-(phenylthio)-1-<(trimethylsilyl)oxy>tricyclo<5.3.1.0^2,6>undecane

There total 2 articles about (1RS,2SR,7RS,9RS,11SR)-6-aza-11-(carbomethoxymethyl)-9-(phenylthio)-1-<(trimethylsilyl)oxy>tricyclo<5.3.1.0^2,6>undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((1R,6R,7S,8S,9R)-9-Hydroxy-7-trimethylsilanyloxy-2-aza-tricyclo[5.3.1.02,6]undec-8-yl)-acetic acid methyl ester (94707-76-3) → (1RS,2SR,7RS,9RS,11SR)-6-aza-11-(carbomethoxymethyl)-9-(phenylthio)-1-<(trimethylsilyl)oxy>tricyclo<5.3.1.02,6>undecane (94707-75-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / Et₃N / CH₂Cl₂ / Ambient temperature

2: 1.) NaH / 1.) DMF, 30 min, 2.) 80 deg C, 2.5 h

With sodium hydride; triethylamine; In dichloromethane;

DOI:10.1021/jo00207a012

Reference yield:

thiophenol (108-98-5) + (1RS,2SR,7SR,9SR,10RS)-6-aza-10-(carbomethoxymethyl)-9-<(methylsulfonyl)oxy>-1-<(trimethylsilyl)oxy>tricyclo<5.3.1.02,6>undecane (94707-73-0) → (1RS,2SR,7RS,9RS,11SR)-6-aza-11-(carbomethoxymethyl)-9-(phenylthio)-1-<(trimethylsilyl)oxy>tricyclo<5.3.1.02,6>undecane (94707-75-2)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 30 min, 2.) 80 deg C, 2.5 h;

DOI:10.1021/jo00207a012

upstream raw materials:

thiophenol

(1RS,2SR,7SR,9SR,10RS)-6-aza-10-(carbomethoxymethyl)-9-<(methylsulfonyl)oxy>-1-<(trimethylsilyl)oxy>tricyclo<5.3.1.0^2,6>undecane

((1R,6R,7S,8S,9R)-9-Hydroxy-7-trimethylsilanyloxy-2-aza-tricyclo[5.3.1.0^2,6]undec-8-yl)-acetic acid methyl ester