1H-Pyrrole, 2-[4-(trifluoromethyl)phenyl]-

Base Information

• Chemical Name: 1H-Pyrrole, 2-[4-(trifluoromethyl)phenyl]-
• CAS No.: 115464-88-5
• Molecular Formula: C11H8F3N
• Molecular Weight: 211.186
• Mol file: 115464-88-5.mol

Synonyms:2-(4-(trifluoromethyl)phenyl)-1H-pyrrole;2-(4-Trifluoromethyl-phenyl)-1H-pyrrole;2-[4-(trifluoromethyl)phenyl]-1H-pyrrole;2-(4-trifluoromethylphenyl)pyrrole;

Chemical Property of 1H-Pyrrole, 2-[4-(trifluoromethyl)phenyl]-

Chemical Property:

• PSA: 15.79000
• LogP: 3.70050

Purity/Quality:

97% ^*data from raw suppliers

2-[4-(Trifluoromethyl)phenyl]pyrrole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrrole, 2-[4-(trifluoromethyl)phenyl]-

There total 9 articles about 1H-Pyrrole, 2-[4-(trifluoromethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

pyrrole (109-97-7,30604-81-0) + p-trifluoromethylphenyl bromide (402-43-7) → 2-<4-(trifluoromethyl)phenyl>pyrrole (115464-88-5)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); potassium acetate; In N,N-dimethyl acetamide; at 130 ℃; for 8h; Inert atmosphere;

DOI:10.1055/s-0036-1588780

Reference yield: 86.0%

4-oxo-4-[4-(trifluoromethyl)phenyl]butanal (117729-42-7) → 2-<4-(trifluoromethyl)phenyl>pyrrole (115464-88-5)

Guidance literature:

With ammonium acetate; In ethanol; for 1.5h; Heating;

Reference yield: 80.0%

1-(1-azidocyclobutyl)-4-(trifluoromethyl)benzene → 2-<4-(trifluoromethyl)phenyl>pyrrole (115464-88-5)

Guidance literature:

1-(1-azidocyclobutyl)-4-(trifluoromethyl)benzene; In o-xylene; at 160 ℃; for 24h; Inert atmosphere;

With palladium 10% on activated carbon; In o-xylene; at 160 ℃; for 4h; Reflux;

DOI:10.1002/adsc.202100329

upstream raw materials:

4-oxo-4-[4-(trifluoromethyl)phenyl]butanal

4-trifluoromethyl-phenyl acetyl chloride

N-methoxy-N-methyl-4-trifluoromethylbenzamide

2-<2-(4-trifluoromethylbenzoyl)ethyl>-1,3-dioxolane

Downstream raw materials:

5-<(4-trifluoromethyl)phenyl>-2-<<4-(2-methoxyphenyl)-1-piperazinyl>methyl>pyrrole

Ti(NMe₂)2(2-[4-(trifluoromethyl)phenyl]pyrrolyl)2