[(S)-4-{2-[((S)-2-Benzyloxycarbonylamino-3-tert-butoxy-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetyl}-2-oxo-3-(1-trityl-1H-imidazol-4-ylmethyl)-piperazin-1-yl]-acetic acid

Base Information

Chemical Name:[(S)-4-{2-[((S)-2-Benzyloxycarbonylamino-3-tert-butoxy-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetyl}-2-oxo-3-(1-trityl-1H-imidazol-4-ylmethyl)-piperazin-1-yl]-acetic acid
CAS No.:1025885-66-8
Molecular Formula:C₅₀H₅₈N₆O₁₀
Molecular Weight:903.045
Hs Code.:

[(S)-4-{2-[((S)-2-Benzyloxycarbonylamino-3-tert-butoxy-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetyl}-2-oxo-3-(1-trityl-1H-imidazol-4-ylmethyl)-piperazin-1-yl]-acetic acid

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Chemical Property of [(S)-4-{2-[((S)-2-Benzyloxycarbonylamino-3-tert-butoxy-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetyl}-2-oxo-3-(1-trityl-1H-imidazol-4-ylmethyl)-piperazin-1-yl]-acetic acid

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Technology Process of [(S)-4-{2-[((S)-2-Benzyloxycarbonylamino-3-tert-butoxy-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetyl}-2-oxo-3-(1-trityl-1H-imidazol-4-ylmethyl)-piperazin-1-yl]-acetic acid

There total 8 articles about [(S)-4-{2-[((S)-2-Benzyloxycarbonylamino-3-tert-butoxy-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetyl}-2-oxo-3-(1-trityl-1H-imidazol-4-ylmethyl)-piperazin-1-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 185117-65-1
(S)-2-(1H-Imidazol-4-ylmethyl)-4-methoxycarbonylmethyl-3-oxo-3,4-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester

: 1025885-66-8
[(S)-4-{2-[((S)-2-Benzyloxycarbonylamino-3-tert-butoxy-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetyl}-2-oxo-3-(1-trityl-1H-imidazol-4-ylmethyl)-piperazin-1-yl]-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C / methanol

2: TEA / CH₂Cl₂

3: 4N aq. HCl / dioxane

4: ethyl((dimethylamino)propyl)carbodiimide hydrochloride, hydroxybenzotriazole, DIPEA / dimethylformamide

5: NaOH / methanol

With hydrogenchloride; sodium hydroxide; TEA; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1228

Reference yield:

: [[(S)-2-tert-Butoxycarbonylamino-3-(1H-imidazol-4-yl)-propionyl]-(2,2-dimethoxy-ethyl)-amino]-acetic acid methyl ester

: 1025885-66-8
[(S)-4-{2-[((S)-2-Benzyloxycarbonylamino-3-tert-butoxy-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetyl}-2-oxo-3-(1-trityl-1H-imidazol-4-ylmethyl)-piperazin-1-yl]-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: p-TsOH / toluene

2: H₂ / Pd/C / methanol

3: TEA / CH₂Cl₂

4: 4N aq. HCl / dioxane

5: ethyl((dimethylamino)propyl)carbodiimide hydrochloride, hydroxybenzotriazole, DIPEA / dimethylformamide

6: NaOH / methanol

With hydrogenchloride; sodium hydroxide; TEA; hydrogen; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.45.1228

Reference yield:

: 76-83-5
trityl chloride

: 1025885-66-8
[(S)-4-{2-[((S)-2-Benzyloxycarbonylamino-3-tert-butoxy-propionyl)-(2,2-dimethoxy-ethyl)-amino]-acetyl}-2-oxo-3-(1-trityl-1H-imidazol-4-ylmethyl)-piperazin-1-yl]-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: TEA / CH₂Cl₂

2: 4N aq. HCl / dioxane

3: ethyl((dimethylamino)propyl)carbodiimide hydrochloride, hydroxybenzotriazole, DIPEA / dimethylformamide

4: NaOH / methanol

With hydrogenchloride; sodium hydroxide; TEA; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1228