5'-O-(4-Methoxytrityl)-thymidinylacetamido-3(C)-5'(C)>-N6-(4-methoxytrityl)-5',2'-dideoxyadenosine

Base Information

Chemical Name:5'-O-(4-Methoxytrityl)-thymidinylacetamido-3(C)-5'(C)>-N6-(4-methoxytrityl)-5',2'-dideoxyadenosine
CAS No.:129789-19-1
Molecular Formula:C₆₂H₆₀N₈O₁₀
Molecular Weight:1077.21
Hs Code.:

5'-O-(4-Methoxytrityl)-thymidinylacetamido-<N<sup>3</sup>(C)-5'(C)>-N6-(4-methoxytrityl)-5',2'-dideoxyadenosine

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Chemical Property of 5'-O-(4-Methoxytrityl)-thymidinylacetamido-3(C)-5'(C)>-N6-(4-methoxytrityl)-5',2'-dideoxyadenosine

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Technology Process of 5'-O-(4-Methoxytrityl)-thymidinylacetamido-3(C)-5'(C)>-N6-(4-methoxytrityl)-5',2'-dideoxyadenosine

There total 6 articles about 5'-O-(4-Methoxytrityl)-thymidinylacetamido-3(C)-5'(C)>-N6-(4-methoxytrityl)-5',2'-dideoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 129789-10-2
5'-Amino-6-N-(4-monomethoxytriphenylmethyl)-5',2'-dideoxyadenosine

: Sodium; (3-{(2R,4S,5R)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl)-acetate

: 129789-19-1
5'-O-(4-Methoxytrityl)-thymidinylacetamido-3(C)-5'(C)>-N6-(4-methoxytrityl)-5',2'-dideoxyadenosine

Guidance literature:: With N-ethylmorpholine;; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)89780-5

Reference yield:

: 129789-01-1
6-N-(4-Monomethoxytriphenylmethyl)-2'-deoxyadenosine

: 129789-19-1
5'-O-(4-Methoxytrityl)-thymidinylacetamido-3(C)-5'(C)>-N6-(4-methoxytrityl)-5',2'-dideoxyadenosine

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / pyridine / 48 h / 5 °C

2: 93 percent / NaN₃ / dimethylsulfoxide / 2 h / Heating

3: 1) Ph₃P, pyridine, 2) methanolic ammonia / 1a) 1h, 0 deg C, 1b) 20 deg C, overnight

4: 50 percent / 1-hydroxybenzotriazole, N-ethylmorpholine, dicyclohexylcarbodiimide / dimethylformamide

With N-ethylmorpholine;; pyridine; sodium azide; ammonia; benzotriazol-1-ol; dicyclohexyl-carbodiimide; triphenylphosphine; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)89780-5

Reference yield:

: 129789-07-7
5'-Azido-6-N-(4-monomethoxytriphenylmethyl)-5',2'-dideoxyadenosine

: 129789-19-1
5'-O-(4-Methoxytrityl)-thymidinylacetamido-3(C)-5'(C)>-N6-(4-methoxytrityl)-5',2'-dideoxyadenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 1) Ph₃P, pyridine, 2) methanolic ammonia / 1a) 1h, 0 deg C, 1b) 20 deg C, overnight

2: 50 percent / 1-hydroxybenzotriazole, N-ethylmorpholine, dicyclohexylcarbodiimide / dimethylformamide

With N-ethylmorpholine;; pyridine; ammonia; benzotriazol-1-ol; dicyclohexyl-carbodiimide; triphenylphosphine; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)89780-5