(+/-)-trans-(E)-2--4-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-3-butenenitrile

Base Information

Chemical Name:(+/-)-trans-(E)-2--4-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-3-butenenitrile
CAS No.:128999-47-3
Molecular Formula:C₂₂H₁₇F₂NO₃
Molecular Weight:381.379
Hs Code.:

(+/-)-trans-(E)-2-<bis(4-fluorophenyl)methylene>-4-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-3-butenenitrile

Synonyms:

Suppliers and Price of (+/-)-trans-(E)-2--4-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-3-butenenitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+/-)-trans-(E)-2--4-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-3-butenenitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+/-)-trans-(E)-2--4-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-3-butenenitrile

There total 10 articles about (+/-)-trans-(E)-2--4-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-3-butenenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128995-67-5,130200-51-0
(+/-)-(E)-erythro-8-cyano-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-6,8-nonadienoic acid

: 128999-47-3,130273-22-2
(+/-)-trans-(E)-2--4-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-3-butenenitrile

Guidance literature:: With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; In dichloromethane; for 12h; Yield given; Ambient temperature;
DOI:10.1021/jm00173a013

Reference yield:

: 128995-63-1
2-cyano-3,3-bis(4-fluorophenyl)-2-propenal

: 128999-47-3,130273-22-2
(+/-)-trans-(E)-2--4-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-3-butenenitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / benzene / 1 h / Heating

3: 72 percent / 1.) Et₃B, 2.) NaBH₄ / tetrahydrofuran; methanol / 1.) 0 deg C, 1 h, 2.) -78 deg C, 3.5 h

4: 1.0 M aq. NaOH / tetrahydrofuran / 2 h / 0 °C

5: 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulphonate / CH₂Cl₂ / 12 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; triethyl borane; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1021/jm00173a013

Reference yield:

: 128995-65-3
2-cyano-3,3-bis(4-fluorophenyl)-2-propenol

: 128999-47-3,130273-22-2
(+/-)-trans-(E)-2--4-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-3-butenenitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / pyridinium chlorochromate (PCC) / CH₂Cl₂ / 16 h / Ambient temperature

2: 100 percent / benzene / 1 h / Heating

4: 72 percent / 1.) Et₃B, 2.) NaBH₄ / tetrahydrofuran; methanol / 1.) 0 deg C, 1 h, 2.) -78 deg C, 3.5 h

5: 1.0 M aq. NaOH / tetrahydrofuran / 2 h / 0 °C

6: 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulphonate / CH₂Cl₂ / 12 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; triethyl borane; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1021/jm00173a013