4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2,6-diamino-1,5-dihydro-7-[(2-methoxyphenyl)methyl]-, monohydrochloride

Base Information

Chemical Name:4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2,6-diamino-1,5-dihydro-7-[(2-methoxyphenyl)methyl]-, monohydrochloride
CAS No.:115787-71-8
Molecular Formula:C₁₄H₁₅N₅O₂*ClH
Molecular Weight:321.766
Hs Code.:

Synonyms:

Suppliers and Price of 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2,6-diamino-1,5-dihydro-7-[(2-methoxyphenyl)methyl]-, monohydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2,6-diamino-1,5-dihydro-7-[(2-methoxyphenyl)methyl]-, monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2,6-diamino-1,5-dihydro-7-[(2-methoxyphenyl)methyl]-, monohydrochloride

There total 6 articles about 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2,6-diamino-1,5-dihydro-7-[(2-methoxyphenyl)methyl]-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 140676-89-7
2-(2,5-Diamino-6-oxo-1,6-dihydro-pyrimidin-4-yl)-3-(2-methoxy-phenyl)-propionitrile

: 115787-71-8
2,6-diamino-3,5-dihydro-7-<(2-methoxyphenyl)methyl>-4H-pyrrolo<3,2-d>pyrimidin-4-one hydrochloride

Guidance literature:: With hydrogenchloride; 1.) RT, 2 h, 2.) from 47 deg C to 55 deg C, 45 min;
DOI:10.1021/jm00087a015

Reference yield:

: 72955-39-6
methyl 2-cyano-3-(2-methoxyphenyl)acrylate

: 115787-71-8
2,6-diamino-3,5-dihydro-7-<(2-methoxyphenyl)methyl>-4H-pyrrolo<3,2-d>pyrimidin-4-one hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 62.3 percent / NaBH₄, 1N NaOH / methanol; H₂O / 17 h / Ambient temperature

2: 1.) t-BuOK / 1.) DMSO, RT, 40 min, 2.) DMSO, a) RT 80 min, b) 65 deg C, 19 h

3: 78.3 percent / 1N NaOH / 3.75 h / Ambient temperature

4: 56.76 g / Na₂S₂O₄, 1N NaOH / 1.17 h / Heating

5: 35 percent / concd. HCl / 1.) RT, 2 h, 2.) from 47 deg C to 55 deg C, 45 min

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; sodium dithionite; potassium tert-butylate; In methanol; water;
DOI:10.1021/jm00087a015

Reference yield:

: 135-02-4
ortho-anisaldehyde

: 115787-71-8
2,6-diamino-3,5-dihydro-7-<(2-methoxyphenyl)methyl>-4H-pyrrolo<3,2-d>pyrimidin-4-one hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 73.4 percent / piperidine / dioxane / 1.) 0 deg C, 2 h, 2.) RT, 18 h

2: 62.3 percent / NaBH₄, 1N NaOH / methanol; H₂O / 17 h / Ambient temperature

3: 1.) t-BuOK / 1.) DMSO, RT, 40 min, 2.) DMSO, a) RT 80 min, b) 65 deg C, 19 h

4: 78.3 percent / 1N NaOH / 3.75 h / Ambient temperature

5: 56.76 g / Na₂S₂O₄, 1N NaOH / 1.17 h / Heating

6: 35 percent / concd. HCl / 1.) RT, 2 h, 2.) from 47 deg C to 55 deg C, 45 min

With piperidine; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; sodium dithionite; potassium tert-butylate; In 1,4-dioxane; methanol; water;
DOI:10.1021/jm00087a015