4-[3-(2,4-bis-benzyloxy-5-chloro-phenyl)-5-tert-butoxycarbonyl-1-(toluene-4-sulfonyl)-1H-pyrazol-4-yl]-piperazine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-[3-(2,4-bis-benzyloxy-5-chloro-phenyl)-5-tert-butoxycarbonyl-1-(toluene-4-sulfonyl)-1H-pyrazol-4-yl]-piperazine-1-carboxylic acid tert-butyl ester
• CAS No.: 719288-44-5
• Molecular Formula: C₄₄H₄₉ClN₄O₈S
• Molecular Weight: 829.414
• Mol file: 719288-44-5.mol

Synonyms:

Chemical Property of 4-[3-(2,4-bis-benzyloxy-5-chloro-phenyl)-5-tert-butoxycarbonyl-1-(toluene-4-sulfonyl)-1H-pyrazol-4-yl]-piperazine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[3-(2,4-bis-benzyloxy-5-chloro-phenyl)-5-tert-butoxycarbonyl-1-(toluene-4-sulfonyl)-1H-pyrazol-4-yl]-piperazine-1-carboxylic acid tert-butyl ester

There total 7 articles about 4-[3-(2,4-bis-benzyloxy-5-chloro-phenyl)-5-tert-butoxycarbonyl-1-(toluene-4-sulfonyl)-1H-pyrazol-4-yl]-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[3-(2,4-bis-benzyloxy-5-chloro-phenyl)-1-(toluene-4-sulphonyl)-1H-pyrazol-4-yl]-piperazine-1-carboxylic acid tert-butyl ester (719288-22-9) + tert-butyl chloroformate (24608-52-4) → 4-[3-(2,4-bis-benzyloxy-5-chloro-phenyl)-5-tert-butoxycarbonyl-1-(toluene-4-sulfonyl)-1H-pyrazol-4-yl]-piperazine-1-carboxylic acid tert-butyl ester (719288-44-5)

Guidance literature:

4-[3-(2,4-bis-benzyloxy-5-chloro-phenyl)-1-(toluene-4-sulphonyl)-1H-pyrazol-4-yl]-piperazine-1-carboxylic acid tert-butyl ester; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.166667h;

tert-butyl chloroformate; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2006.01.099

Reference yield:

1-[2,4-bis(benzyloxy)-5-chlorophenyl]ethan-1-one (705963-54-8) → 4-[3-(2,4-bis-benzyloxy-5-chloro-phenyl)-5-tert-butoxycarbonyl-1-(toluene-4-sulfonyl)-1H-pyrazol-4-yl]-piperazine-1-carboxylic acid tert-butyl ester (719288-44-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 50 percent / PhMe₃N(+)*Br₃(-) / tetrahydrofuran / 2 h / 20 °C

2.1: 81 percent / Cs₂CO₃ / dimethylformamide / 2 h / 20 °C

3.1: 7 h / Heating

3.2: hydrazine / ethanol / 0.08 h / 120 °C / microwave irradiation

4.1: 77 percent / pyridine / CH₂Cl₂ / 20 °C

5.1: n-BuLi / tetrahydrofuran / 0.17 h / -78 °C

5.2: tetrahydrofuran / 0 - 20 °C

With pyridine; n-butyllithium; phenyltrimethylammonium tribromide; caesium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.01.099

Reference yield:

1-(2,4-bis-benzyloxy-5-chloro-phenyl)-2-bromo-ethanone (719288-16-1) → 4-[3-(2,4-bis-benzyloxy-5-chloro-phenyl)-5-tert-butoxycarbonyl-1-(toluene-4-sulfonyl)-1H-pyrazol-4-yl]-piperazine-1-carboxylic acid tert-butyl ester (719288-44-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 81 percent / Cs₂CO₃ / dimethylformamide / 2 h / 20 °C

2.1: 7 h / Heating

2.2: hydrazine / ethanol / 0.08 h / 120 °C / microwave irradiation

3.1: 77 percent / pyridine / CH₂Cl₂ / 20 °C

4.1: n-BuLi / tetrahydrofuran / 0.17 h / -78 °C

4.2: tetrahydrofuran / 0 - 20 °C

With pyridine; n-butyllithium; caesium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.01.099

upstream raw materials:

4-[3-(2,4-bis-benzyloxy-5-chloro-phenyl)-1-(toluene-4-sulphonyl)-1H-pyrazol-4-yl]-piperazine-1-carboxylic acid tert-butyl ester

tert-butyl chloroformate

1-[2,4-bis(benzyloxy)-5-chlorophenyl]ethan-1-one

1-(2,4-bis-benzyloxy-5-chloro-phenyl)-2-bromo-ethanone