(S)-2-((S)-2-{[(S)-2-({(S)-2-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-4-methyl-pentanoyl}-methyl-amino)-3-methyl-butyryl]-methyl-amino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid methyl ester

Base Information

• Chemical Name: (S)-2-((S)-2-{[(S)-2-({(S)-2-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-4-methyl-pentanoyl}-methyl-amino)-3-methyl-butyryl]-methyl-amino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid methyl ester
• CAS No.: 909108-71-0
• Molecular Formula: C₄₁H₆₉N₅O₈
• Molecular Weight: 760.028

Synonyms:

Chemical Property of (S)-2-((S)-2-{[(S)-2-({(S)-2-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-4-methyl-pentanoyl}-methyl-amino)-3-methyl-butyryl]-methyl-amino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (S)-2-((S)-2-{[(S)-2-({(S)-2-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-4-methyl-pentanoyl}-methyl-amino)-3-methyl-butyryl]-methyl-amino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid methyl ester

There total 8 articles about (S)-2-((S)-2-{[(S)-2-({(S)-2-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-4-methyl-pentanoyl}-methyl-amino)-3-methyl-butyryl]-methyl-amino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid (863781-44-6) + (S)-2-{(S)-4-Methyl-2-[methyl-((S)-3-methyl-2-methylamino-butyryl)-amino]-pentanoylamino}-3-phenyl-propionic acid methyl ester → (S)-2-((S)-2-{[(S)-2-({(S)-2-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-4-methyl-pentanoyl}-methyl-amino)-3-methyl-butyryl]-methyl-amino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid methyl ester (909108-71-0)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

DOI:10.1016/j.bmc.2006.04.031

Reference yield:

N-t-butoxycarbonyl-N-methyl-L-leucine (53363-89-6) → (S)-2-((S)-2-{[(S)-2-({(S)-2-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-4-methyl-pentanoyl}-methyl-amino)-3-methyl-butyryl]-methyl-amino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid methyl ester (909108-71-0)

Guidance literature:

Multi-step reaction with 3 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*BF₄^(1-); diisopropylethylamine / CH₂Cl₂ / 20 °C

2: lithium hydroxide / methanol

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*BF₄^(1-); diisopropylethylamine / acetonitrile / 20 °C

With lithium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetonitrile;

DOI:10.1016/j.bmc.2006.04.031

Reference yield:

N-(tert-butoxycarbonyl)-N-methyl-L-leucyl-L-phenylalanine methyl ester (863781-38-8) → (S)-2-((S)-2-{[(S)-2-({(S)-2-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-4-methyl-pentanoyl}-methyl-amino)-3-methyl-butyryl]-methyl-amino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid methyl ester (909108-71-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / trifluoroacetic acid; anisole / CH₂Cl₂

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*BF₄^(1-); diisopropylethylamine / CH₂Cl₂ / 20 °C

3: trifluoroacetic acid; anisole / CH₂Cl₂

4: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*BF₄^(1-); diisopropylethylamine / acetonitrile / 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;

DOI:10.1016/j.bmc.2006.04.031

upstream raw materials:

(S)-2-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid

N-(tert-butoxycarbonyl)-N-methyl-L-leucyl-L-phenylalanine methyl ester

(S)-2-((S)-2-{[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-3-methyl-butyryl]-methyl-amino}-4-methyl-pentanoylamino)-3-phenyl-propionic acid methyl ester

(S)-Leu-OMe

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