Technology Process of methyl 3-chloro-5-[(2,4-difluoro-5-phenylphenyl)sulfamoyl]-4-hydroxybenzoate
There total 8 articles about methyl 3-chloro-5-[(2,4-difluoro-5-phenylphenyl)sulfamoyl]-4-hydroxybenzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron tribromide;
In
dichloromethane;
at 0 ℃;
for 12h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogen; platinum on activated charcoal / acetonitrile / 25 °C
2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / toluene; ethanol; water / 12 h / 80 °C / Inert atmosphere
3: pyridine / 12 h / 50 °C / Inert atmosphere
4: boron tribromide / dichloromethane / 12 h / 0 °C / Inert atmosphere
With
pyridine; tetrakis(triphenylphosphine) palladium(0); platinum on activated charcoal; hydrogen; boron tribromide; potassium carbonate;
In
ethanol; dichloromethane; water; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / toluene; ethanol; water / 12 h / 80 °C / Inert atmosphere
2: pyridine / 12 h / 50 °C / Inert atmosphere
3: boron tribromide / dichloromethane / 12 h / 0 °C / Inert atmosphere
With
pyridine; tetrakis(triphenylphosphine) palladium(0); boron tribromide; potassium carbonate;
In
ethanol; dichloromethane; water; toluene;
