[(1S)-1-((1S)-1-{1-benzylcarbamoyl-1-[2-(tert-butyldiphenylsiloxy)ethyl]butylcarbamoyl}-2-(thiazol-4-yl)ethylcarbamoyl)ethyl]carbamic acid tert-butyl ester

Base Information

Chemical Name:[(1S)-1-((1S)-1-{1-benzylcarbamoyl-1-[2-(tert-butyldiphenylsiloxy)ethyl]butylcarbamoyl}-2-(thiazol-4-yl)ethylcarbamoyl)ethyl]carbamic acid tert-butyl ester
CAS No.:872983-64-7
Molecular Formula:C₄₄H₅₉N₅O₆SSi
Molecular Weight:814.134
Hs Code.:

[(1S)-1-((1S)-1-{1-benzylcarbamoyl-1-[2-(tert-butyldiphenylsiloxy)ethyl]butylcarbamoyl}-2-(thiazol-4-yl)ethylcarbamoyl)ethyl]carbamic acid tert-butyl ester

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Chemical Property of [(1S)-1-((1S)-1-{1-benzylcarbamoyl-1-[2-(tert-butyldiphenylsiloxy)ethyl]butylcarbamoyl}-2-(thiazol-4-yl)ethylcarbamoyl)ethyl]carbamic acid tert-butyl ester

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Technology Process of [(1S)-1-((1S)-1-{1-benzylcarbamoyl-1-[2-(tert-butyldiphenylsiloxy)ethyl]butylcarbamoyl}-2-(thiazol-4-yl)ethylcarbamoyl)ethyl]carbamic acid tert-butyl ester

There total 9 articles about [(1S)-1-((1S)-1-{1-benzylcarbamoyl-1-[2-(tert-butyldiphenylsiloxy)ethyl]butylcarbamoyl}-2-(thiazol-4-yl)ethylcarbamoyl)ethyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 872983-37-4
2-amino-2-(2-hydroxy-ethyl)-pent-4-enoic acid

: 872983-64-7
[(1S)-1-((1S)-1-{1-benzylcarbamoyl-1-[2-(tert-butyldiphenylsiloxy)ethyl]butylcarbamoyl}-2-(thiazol-4-yl)ethylcarbamoyl)ethyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: H₂ / Pd-C / methanol / 14 h / 20 °C

2: 2.4 g / hydrochloric acid / 16 h / Heating

3: 97 percent / 2-phenylbenzoxazole; ethyldiisopropylamine / CH₂Cl₂ / 0 °C

4: lithium hydroxide / tetrahydrofuran; H₂O / 0 °C

5: 1.61 g / imidazole / CH₂Cl₂ / 0 °C

6: 1.45 g / 1-hydroxy-1H-benzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; triethylamine / CH₂Cl₂ / 0 °C

7: 26 percent / trifluoroacetic acid / CH₂Cl₂ / 0 °C

8: 0.1 g / 1-hydroxy-1H-benzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; triethylamine / CH₂Cl₂ / 0 °C

With 1H-imidazole; hydrogenchloride; lithium hydroxide; 2-phenylbenzo[d]oxazole; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2005.08.019

Reference yield:

: C₁₆H₂₈NO₄S⁽¹⁺⁾*BF₄^(1-)

: 872983-64-7
[(1S)-1-((1S)-1-{1-benzylcarbamoyl-1-[2-(tert-butyldiphenylsiloxy)ethyl]butylcarbamoyl}-2-(thiazol-4-yl)ethylcarbamoyl)ethyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: sodium hydroxide / 16 h / Heating

2: H₂ / Pd-C / methanol / 14 h / 20 °C

3: 2.4 g / hydrochloric acid / 16 h / Heating

4: 97 percent / 2-phenylbenzoxazole; ethyldiisopropylamine / CH₂Cl₂ / 0 °C

5: lithium hydroxide / tetrahydrofuran; H₂O / 0 °C

6: 1.61 g / imidazole / CH₂Cl₂ / 0 °C

7: 1.45 g / 1-hydroxy-1H-benzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; triethylamine / CH₂Cl₂ / 0 °C

8: 26 percent / trifluoroacetic acid / CH₂Cl₂ / 0 °C

9: 0.1 g / 1-hydroxy-1H-benzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; triethylamine / CH₂Cl₂ / 0 °C

With 1H-imidazole; hydrogenchloride; lithium hydroxide; sodium hydroxide; 2-phenylbenzo[d]oxazole; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2005.08.019

Reference yield:

: 872984-03-7
2-(2-amino-3-thiazol-4-yl-propionylamino)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pentanoic acid benzylamide

: 15761-38-3
L-N-Boc-Ala

: 872983-64-7
[(1S)-1-((1S)-1-{1-benzylcarbamoyl-1-[2-(tert-butyldiphenylsiloxy)ethyl]butylcarbamoyl}-2-(thiazol-4-yl)ethylcarbamoyl)ethyl]carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1016/j.bmc.2005.08.019