Isoquinoline, 2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-1-[(3,4-dimethoxyphen yl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, (1R)-

Base Information

Chemical Name:Isoquinoline, 2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-1-[(3,4-dimethoxyphen yl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, (1R)-
CAS No.:116071-85-3
Molecular Formula:C₂₆H₃₄N₂O₅
Molecular Weight:454.566
Hs Code.:
Mol file:116071-85-3.mol

Synonyms:

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Chemical Property of Isoquinoline, 2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-1-[(3,4-dimethoxyphen yl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, (1R)-

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Isoquinoline, 2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-1-[(3,4-dimethoxyphen yl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, (1R)-

There total 4 articles about Isoquinoline, 2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-1-[(3,4-dimethoxyphen yl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, (1R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 102922-34-9
2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 7306-46-9
4-chloromethyl-1,2-dimethoxy-benzene

: 119110-16-6
(S)-1-(3,4-Dimethoxy-benzyl)-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline

: 116071-85-3
(R)-1-(3,4-Dimethoxy-benzyl)-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: With tert.-butyl lithium; In tetrahydrofuran; at -100 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1016/S0040-4039(00)80079-9

Reference yield:

: 1745-07-9
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 116071-85-3
(R)-1-(3,4-Dimethoxy-benzyl)-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / TsOH / benzene / Heating

2: t-BuLi / tetrahydrofuran / -100 °C

With tert.-butyl lithium; toluene-4-sulfonic acid; In tetrahydrofuran; benzene;
DOI:10.1016/S0040-4039(00)80079-9

Reference yield:

: 102922-29-2
(S)-2-ethoxy-4,5-dihydro-4-(1-methylethyl)oxazole

: 116071-85-3
(R)-1-(3,4-Dimethoxy-benzyl)-2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / TsOH / benzene / Heating

2: t-BuLi / tetrahydrofuran / -100 °C

With tert.-butyl lithium; toluene-4-sulfonic acid; In tetrahydrofuran; benzene;
DOI:10.1016/S0040-4039(00)80079-9