Technology Process of (3aS,4S,7S,7aR)-2-Benzoyl-1-benzyl-4-ethoxycarbonyloxymethyl-6,7-dimethyl-3-oxo-1,2,3,4,7,7a-hexahydro-isoindole-3a-carboxylic acid ethyl ester
There total 7 articles about (3aS,4S,7S,7aR)-2-Benzoyl-1-benzyl-4-ethoxycarbonyloxymethyl-6,7-dimethyl-3-oxo-1,2,3,4,7,7a-hexahydro-isoindole-3a-carboxylic acid ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 77 percent / sodium hydride / tetrahydrofuran / 0 °C
2: LDA, hexamethylphosphoramide / 1.) THF, -78 deg C, 45 min, 2.) -78 deg C to RT, 2 h
3: 1.) LDA, HMPA / 1.) THF, -78 deg C, 45 min, 2.) -78 deg C to RT, 2 h
4: 64 percent / 30percent H2O2, glacial acetic acid / H2O; tetrahydrofuran / 2 h / 0 °C
5: 17 mg / benzene-d6 / 1 h / 125 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; dihydrogen peroxide; sodium hydride; acetic acid; lithium diisopropyl amide;
In
tetrahydrofuran; benzene-d6; water;
DOI:10.1021/jo00347a034
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 73 percent / pyridine / 1 h / Ambient temperature
2: 17 mg / benzene-d6 / 1 h / 125 °C
With
pyridine;
In
benzene-d6;
DOI:10.1021/jo00347a034
- Guidance literature:
-
Multi-step reaction with 4 steps
1: LDA, hexamethylphosphoramide / 1.) THF, -78 deg C, 45 min, 2.) -78 deg C to RT, 2 h
2: 1.) LDA, HMPA / 1.) THF, -78 deg C, 45 min, 2.) -78 deg C to RT, 2 h
3: 64 percent / 30percent H2O2, glacial acetic acid / H2O; tetrahydrofuran / 2 h / 0 °C
4: 17 mg / benzene-d6 / 1 h / 125 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; dihydrogen peroxide; acetic acid; lithium diisopropyl amide;
In
tetrahydrofuran; benzene-d6; water;
DOI:10.1021/jo00347a034
