1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester

Base Information

• Chemical Name: 1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester
• CAS No.: 116119-01-8
• Molecular Formula: C9H8O5
• Molecular Weight: 196.16
• Mol file: 116119-01-8.mol

Synonyms:7-Hydroxy-1,3-benzodioxole-5-carboxylic Acid Methyl Ester;

Chemical Property of 1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester

Chemical Property:

• PSA: 64.99000
• LogP: 0.90750
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: CDCl3, DCM, Ethanol, Ethyl Acetate,

Purity/Quality:

97% ^*data from raw suppliers

7-Hydroxy-1,3-benzodioxole-5-carboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Hydroxy-1,3-benzodioxole-5-carboxylic Acid Methyl Ester is an intermediate in the synthesis of natural dihydrostilbenes with significant cytotoxicity toward human cancer cell lines.

Technology Process of 1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester

There total 10 articles about 1,3-Benzodioxole-5-carboxylic acid, 7-hydroxy-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 7-(benzyloxy)benzo[d][1,3]dioxole-5-carboxylate (142531-43-9) → methyl 7-hydroxybenzo[d][1,3]dioxole-5-carboxylate (116119-01-8)

Guidance literature:

With titanium tetrachloride; In chloroform; at 20 ℃; for 12h;

DOI:10.1016/j.tet.2004.11.083

Reference yield: 83.0%

→ methyl 2,6-dibromo-3-hydroxy-4,5-(methylenediox)benzoate + methyl 7-hydroxybenzo[d][1,3]dioxole-5-carboxylate (116119-01-8)

Guidance literature:

Reference yield: 60.0%

diiodomethane (75-11-6) + methyl galloate (99-24-1) → methyl 7-hydroxybenzo[d][1,3]dioxole-5-carboxylate (116119-01-8)

Guidance literature:

With potassium carbonate; copper(II) oxide; In N,N-dimethyl-formamide; at 130 ℃; for 5h; Inert atmosphere;

DOI:10.1016/j.tetasy.2009.02.022

upstream raw materials:

diiodomethane

methyl galloate

methyl 7-(benzyloxy)benzo[d][1,3]dioxole-5-carboxylate

7-hydroxy-benzo[1,3]dioxole-5-carboxylic acid

Downstream raw materials:

methyl 7-methoxybenzo[d][1,3]dioxole-5-carboxylate

methyl 3-<4-(dimethoxymethyl)phenoxy>-4,5-(methylenedioxy)benzoate

3-<4-(dimethoxymethyl)phenoxy>-4,5-(methylenedioxy)benzyl alcohol

3-<4-(dimethoxymethyl)phenoxy>-4,5-(methylenedioxy)benzaldehyde