{4-[3-(4-Hydroxy-phenyl)-propionylamino]-butyl}-carbamic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-dodecahydro-benzo[f]chromen-6-yl ester

Base Information

• Chemical Name: {4-[3-(4-Hydroxy-phenyl)-propionylamino]-butyl}-carbamic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-dodecahydro-benzo[f]chromen-6-yl ester
• CAS No.: 136327-90-7
• Molecular Formula: C₃₄H₅₀N₂O₉
• Molecular Weight: 630.779
• Mol file: 136327-90-7.mol

Synonyms:

Chemical Property of {4-[3-(4-Hydroxy-phenyl)-propionylamino]-butyl}-carbamic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-dodecahydro-benzo[f]chromen-6-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {4-[3-(4-Hydroxy-phenyl)-propionylamino]-butyl}-carbamic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-dodecahydro-benzo[f]chromen-6-yl ester

There total 4 articles about {4-[3-(4-Hydroxy-phenyl)-propionylamino]-butyl}-carbamic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-dodecahydro-benzo[f]chromen-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-desacetylforskolin 1,9-dimethylformamide acetal (105535-42-0) → {4-[3-(4-Hydroxy-phenyl)-propionylamino]-butyl}-carbamic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-dodecahydro-benzo[f]chromen-6-yl ester (136327-90-7)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

2: CH₂Cl₂ / 12 h

3: AcOH, MeOH / 12 h

4: dimethylformamide / 2 h / Ambient temperature

With methanol; acetic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00115a009

Reference yield:

7-desacetylforskolin-6,7-carbonate 1,9-(dimethylformamide acetal) (105535-74-8) → {4-[3-(4-Hydroxy-phenyl)-propionylamino]-butyl}-carbamic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-dodecahydro-benzo[f]chromen-6-yl ester (136327-90-7)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂ / 12 h

2: AcOH, MeOH / 12 h

3: dimethylformamide / 2 h / Ambient temperature

With methanol; acetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00115a009

Reference yield:

C28H47N3O7 → {4-[3-(4-Hydroxy-phenyl)-propionylamino]-butyl}-carbamic acid (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-dodecahydro-benzo[f]chromen-6-yl ester (136327-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOH, MeOH / 12 h

2: dimethylformamide / 2 h / Ambient temperature

With methanol; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/jm00115a009

upstream raw materials:

6-<<(4-aminobutyl)amino>carbonyl>-7-desacetylforskolin

7-desacetylforskolin 1,9-dimethylformamide acetal

7-desacetylforskolin-6,7-carbonate 1,9-(dimethylformamide acetal)