(+/-)-11α-phenyl-15-dehydro-11-deoxy-PGE₁ ethyl ester

Base Information

Chemical Name:(+/-)-11α-phenyl-15-dehydro-11-deoxy-PGE₁ ethyl ester
CAS No.:81424-27-3
Molecular Formula:C₂₈H₄₀O₄
Molecular Weight:440.623
Hs Code.:

(+/-)-11α-phenyl-15-dehydro-11-deoxy-PGE<sub>1</sub> ethyl ester

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Chemical Property of (+/-)-11α-phenyl-15-dehydro-11-deoxy-PGE₁ ethyl ester

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Technology Process of (+/-)-11α-phenyl-15-dehydro-11-deoxy-PGE₁ ethyl ester

There total 5 articles about (+/-)-11α-phenyl-15-dehydro-11-deoxy-PGE₁ ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81424-59-1
7-iodo-5-heptynoic acid ethyl ester

: 81424-27-3
(+/-)-11α-phenyl-15-dehydro-11-deoxy-PGE₁ ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: KH / 16 h

2: 99 percent / sodium cyanide / hexamethylphosphoric acid triamide / 6 h / 75 - 80 °C

3: 99 percent / H₂ / Pd/C / ethyl acetate / 16 h

4: 1.) NaH / 1.) dimethoxyethane, room temperature, 1 h, 2.) -78 deg C to -20 deg C, 16 h, 3.) room temperature, 1.5 h

With sodium cyanide; hydrogen; potassium hydride; sodium hydride; palladium on activated charcoal; In N,N,N,N,N,N-hexamethylphosphoric triamide; ethyl acetate;
DOI:10.1021/jo00134a011

Reference yield:

: 81424-22-8
methyl (1R*,2S*,3R*)-2-(dimethoxymethyl)-3-phenyl-5-oxocyclopentanecarboxylate

: 81424-27-3
(+/-)-11α-phenyl-15-dehydro-11-deoxy-PGE₁ ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: KH / 16 h

2: 99 percent / sodium cyanide / hexamethylphosphoric acid triamide / 6 h / 75 - 80 °C

3: 99 percent / H₂ / Pd/C / ethyl acetate / 16 h

4: 1.) NaH / 1.) dimethoxyethane, room temperature, 1 h, 2.) -78 deg C to -20 deg C, 16 h, 3.) room temperature, 1.5 h

With sodium cyanide; hydrogen; potassium hydride; sodium hydride; palladium on activated charcoal; In N,N,N,N,N,N-hexamethylphosphoric triamide; ethyl acetate;
DOI:10.1021/jo00134a011

Reference yield:

: 81424-24-0
ethyl 7-<(1R*,2S*,3R*)-2-(dimethoxymethyl)-5-oxo-3-phenylcyclopentyl>-5-heptynoate

: 81424-27-3
(+/-)-11α-phenyl-15-dehydro-11-deoxy-PGE₁ ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / H₂ / Pd/C / ethyl acetate / 16 h

2: 1.) NaH / 1.) dimethoxyethane, room temperature, 1 h, 2.) -78 deg C to -20 deg C, 16 h, 3.) room temperature, 1.5 h

With hydrogen; sodium hydride; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jo00134a011