ETHOXYCARBONYLMETHYL ETHYL METHYLENEMALONATE

Base Information

• Chemical Name: ETHOXYCARBONYLMETHYL ETHYL METHYLENEMALONATE
• CAS No.: 116280-23-0
• Molecular Formula: C10H14O6
• Molecular Weight: 230.21500
• Mol file: 116280-23-0.mol

Synonyms:ETHOXYCARBONYLMETHYL ETHYL METHYLENEMALONATE;

Chemical Property of ETHOXYCARBONYLMETHYL ETHYL METHYLENEMALONATE

Chemical Property:

• Vapor Pressure: 11.3Pa at 20℃
• Boiling Point: 98-99 °C(Press: 0.1 Torr)
• PSA: 78.90000
• Density: 1.157±0.06 g/cm3(Predicted)
• LogP: 0.21200

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHOXYCARBONYLMETHYL ETHYL METHYLENEMALONATE

There total 7 articles about ETHOXYCARBONYLMETHYL ETHYL METHYLENEMALONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

C5H12N(1+)*C2H3O2(1-) (1448709-78-1) + ethoxycarbonylmethyl ethyl malonate (100074-94-0) → 1-(2-ethoxy-2-oxoethyl) 3-ethyl 2-methylenemalonate (116280-23-0,148184-12-7)

Guidance literature:

With sulfuric acid; In toluene; at 25 - 40 ℃;

Reference yield: 62.0%

C24H24O6 (118969-47-4) → 1-(2-ethoxy-2-oxoethyl) 3-ethyl 2-methylenemalonate (116280-23-0,148184-12-7)

Guidance literature:

With maleic anhydride; In paraffin; at 225 ℃; for 0.75h;

DOI:10.1021/jo00255a038

Reference yield: 57.0%

eschenmoser's salt (33797-51-2) + ethoxycarbonylmethyl ethyl malonate (100074-94-0) → 1-(2-ethoxy-2-oxoethyl) 3-ethyl 2-methylenemalonate (116280-23-0,148184-12-7)

Guidance literature:

With acetyl chloride; at 20 - 50 ℃; for 41h; Time; Reagent/catalyst; Solvent; Concentration;

upstream raw materials:

C₂₄H₂₄O₆

9,10-dihydro-9,10-ethano-anthracene-11,11-dicarboxylic acid diethyl ester

diethyl malonate

C₅H₁₂N⁽¹⁺⁾*C₂H₃O₂^(1-)

Refernces

• 1、 Keyser, Jean-Luc De,Cock, Christian J. C. De,Poupaert, Jacques H.,Dumont, Pierre. "A Versatile and Convenient Multigram Synthesis of Methylidenemalonic Acid Diesters". . p. 4859 - 4862. Retrieved 2007/10/02.