(S)-[(S)-2-{(R)-2-(4-Benzyloxy-phenyl)-2-[(R)-2-tert-butoxycarbonylamino-2-(4-hydroxy-3,5-diiodo-phenyl)-acetylamino]-acetylamino}-3-(3,5-dichloro-4-hydroxy-phenyl)-propionylamino]-(3,5-dimethoxy-phenyl)-acetic acid methyl ester

Base Information

• Chemical Name: (S)-[(S)-2-{(R)-2-(4-Benzyloxy-phenyl)-2-[(R)-2-tert-butoxycarbonylamino-2-(4-hydroxy-3,5-diiodo-phenyl)-acetylamino]-acetylamino}-3-(3,5-dichloro-4-hydroxy-phenyl)-propionylamino]-(3,5-dimethoxy-phenyl)-acetic acid methyl ester
• CAS No.: 173383-19-2
• Molecular Formula: C₄₈H₄₈Cl₂I₂N₄O₁₂
• Molecular Weight: 1197.64
• Mol file: 173383-19-2.mol

Synonyms:

Chemical Property of (S)-[(S)-2-{(R)-2-(4-Benzyloxy-phenyl)-2-[(R)-2-tert-butoxycarbonylamino-2-(4-hydroxy-3,5-diiodo-phenyl)-acetylamino]-acetylamino}-3-(3,5-dichloro-4-hydroxy-phenyl)-propionylamino]-(3,5-dimethoxy-phenyl)-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-[(S)-2-{(R)-2-(4-Benzyloxy-phenyl)-2-[(R)-2-tert-butoxycarbonylamino-2-(4-hydroxy-3,5-diiodo-phenyl)-acetylamino]-acetylamino}-3-(3,5-dichloro-4-hydroxy-phenyl)-propionylamino]-(3,5-dimethoxy-phenyl)-acetic acid methyl ester

There total 6 articles about (S)-[(S)-2-{(R)-2-(4-Benzyloxy-phenyl)-2-[(R)-2-tert-butoxycarbonylamino-2-(4-hydroxy-3,5-diiodo-phenyl)-acetylamino]-acetylamino}-3-(3,5-dichloro-4-hydroxy-phenyl)-propionylamino]-(3,5-dimethoxy-phenyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dimethoxybenzaldehdye (7311-34-4) → (S)-[(S)-2-{(R)-2-(4-Benzyloxy-phenyl)-2-[(R)-2-tert-butoxycarbonylamino-2-(4-hydroxy-3,5-diiodo-phenyl)-acetylamino]-acetylamino}-3-(3,5-dichloro-4-hydroxy-phenyl)-propionylamino]-(3,5-dimethoxy-phenyl)-acetic acid methyl ester (173383-19-2)

Guidance literature:

Multi-step reaction with 5 steps

3: 1.) 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenztriazole, ⁱPr₂EtN; 2.) TFA

4: 1.) 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenztriazole; 2.) TFA

5: 1.) 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenztriazole; 2.) TFA

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;

DOI:10.1016/0040-4039(95)01857-E

Reference yield:

N-t-butoxycarbonyl-3,5-dichloro-L-tyrosine (123418-41-7,1213365-16-2,1259972-62-7) → (S)-[(S)-2-{(R)-2-(4-Benzyloxy-phenyl)-2-[(R)-2-tert-butoxycarbonylamino-2-(4-hydroxy-3,5-diiodo-phenyl)-acetylamino]-acetylamino}-3-(3,5-dichloro-4-hydroxy-phenyl)-propionylamino]-(3,5-dimethoxy-phenyl)-acetic acid methyl ester (173383-19-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenztriazole, ⁱPr₂EtN; 2.) TFA

2: 1.) 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenztriazole; 2.) TFA

3: 1.) 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenztriazole; 2.) TFA

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;

DOI:10.1016/0040-4039(95)01857-E

Reference yield:

Acetylamino-(3,5-dimethoxy-phenyl)-acetic acid (173383-04-5) → (S)-[(S)-2-{(R)-2-(4-Benzyloxy-phenyl)-2-[(R)-2-tert-butoxycarbonylamino-2-(4-hydroxy-3,5-diiodo-phenyl)-acetylamino]-acetylamino}-3-(3,5-dichloro-4-hydroxy-phenyl)-propionylamino]-(3,5-dimethoxy-phenyl)-acetic acid methyl ester (173383-19-2)

Guidance literature:

Multi-step reaction with 4 steps

2: 1.) 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenztriazole, ⁱPr₂EtN; 2.) TFA

3: 1.) 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenztriazole; 2.) TFA

4: 1.) 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenztriazole; 2.) TFA

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;

DOI:10.1016/0040-4039(95)01857-E

upstream raw materials:

(S)-[(S)-2-[(R)-2-Amino-2-(4-benzyloxy-phenyl)-acetylamino]-3-(3,5-dichloro-4-hydroxy-phenyl)-propionylamino]-(3,5-dimethoxy-phenyl)-acetic acid methyl ester

3,5-dimethoxybenzaldehdye

N-t-butoxycarbonyl-3,5-dichloro-L-tyrosine

Acetylamino-(3,5-dimethoxy-phenyl)-acetic acid

Downstream raw materials:

(S)-{[(8R,11R,14S)-8-Amino-11-(4-benzyloxy-phenyl)-18,19-dichloro-4-hydroxy-5-iodo-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carbonyl]-amino}-(3,5-dimethoxy-phenyl)-acetic acid methyl ester

C₆₇H₇₁Cl₄IN₈O₁₇

C₆₇H₇₀Cl₄N₈O₁₇

C₄₈H₄₇Cl₂IN₄O₁₂