(2R,4S)-4-((2E,7E)-(4S,9S)-9-Acetoxy-4,8-dimethyl-6-methylene-undeca-2,7-dienyl)-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxolane-4-carboxylic acid methyl ester

Base Information

• Chemical Name: (2R,4S)-4-((2E,7E)-(4S,9S)-9-Acetoxy-4,8-dimethyl-6-methylene-undeca-2,7-dienyl)-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxolane-4-carboxylic acid methyl ester
• CAS No.: 666715-15-7
• Molecular Formula: C₃₀H₄₂O₆
• Molecular Weight: 498.66
• Mol file: 666715-15-7.mol

Synonyms:

Chemical Property of (2R,4S)-4-((2E,7E)-(4S,9S)-9-Acetoxy-4,8-dimethyl-6-methylene-undeca-2,7-dienyl)-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxolane-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4S)-4-((2E,7E)-(4S,9S)-9-Acetoxy-4,8-dimethyl-6-methylene-undeca-2,7-dienyl)-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxolane-4-carboxylic acid methyl ester

There total 6 articles about (2R,4S)-4-((2E,7E)-(4S,9S)-9-Acetoxy-4,8-dimethyl-6-methylene-undeca-2,7-dienyl)-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxolane-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-(2S,7S)-2,6-Dimethyl-4-methylene-7-(2-trimethylsilanyl-ethoxymethoxy)-non-5-enal (241823-00-7) → (2R,4S)-4-((2E,7E)-(4S,9S)-9-Acetoxy-4,8-dimethyl-6-methylene-undeca-2,7-dienyl)-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxolane-4-carboxylic acid methyl ester (666715-15-7)

Guidance literature:

Multi-step reaction with 7 steps

1: 80 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene; LiCl

2: 93 percent / diisobutylaluminum hydride

3: I₂; PPh₃; imidazole

4: LHMDS / hexamethylphosphoric acid triamide

5: tetraethylammonium fluoride

6: DMAP; pyridine

With pyridine; 1H-imidazole; dmap; iodine; diisobutylaluminium hydride; tetraethylammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; lithium chloride; lithium hexamethyldisilazane; In N,N,N,N,N,N-hexamethylphosphoric triamide; 1: Horner-Wadsworth-Emmons reaction;

DOI:10.1016/j.bmcl.2003.09.072

Reference yield:

[2-((2E,7E)-(1S,6S)-1-Ethyl-9-iodo-2,6-dimethyl-4-methylene-nona-2,7-dienyloxymethoxy)-ethyl]-trimethyl-silane → (2R,4S)-4-((2E,7E)-(4S,9S)-9-Acetoxy-4,8-dimethyl-6-methylene-undeca-2,7-dienyl)-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxolane-4-carboxylic acid methyl ester (666715-15-7)

Guidance literature:

Multi-step reaction with 4 steps

1: LHMDS / hexamethylphosphoric acid triamide

2: tetraethylammonium fluoride

3: DMAP; pyridine

With pyridine; dmap; tetraethylammonium fluoride; lithium hexamethyldisilazane; In N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1016/j.bmcl.2003.09.072

Reference yield:

(2E,7E)-(4S,9S)-4,8-Dimethyl-6-methylene-9-(2-trimethylsilanyl-ethoxymethoxy)-undeca-2,7-dien-1-ol (594854-64-5) → (2R,4S)-4-((2E,7E)-(4S,9S)-9-Acetoxy-4,8-dimethyl-6-methylene-undeca-2,7-dienyl)-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxolane-4-carboxylic acid methyl ester (666715-15-7)

Guidance literature:

Multi-step reaction with 5 steps

1: I₂; PPh₃; imidazole

2: LHMDS / hexamethylphosphoric acid triamide

3: tetraethylammonium fluoride

4: DMAP; pyridine

With pyridine; 1H-imidazole; dmap; iodine; tetraethylammonium fluoride; triphenylphosphine; lithium hexamethyldisilazane; In N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1016/j.bmcl.2003.09.072

upstream raw materials:

(E)-(2S,7S)-2,6-Dimethyl-4-methylene-7-(2-trimethylsilanyl-ethoxymethoxy)-non-5-enal

(2E,7E)-(4S,9S)-4,8-Dimethyl-6-methylene-9-(2-trimethylsilanyl-ethoxymethoxy)-undeca-2,7-dien-1-ol

(2E,7E)-(4S,9S)-4,8-Dimethyl-6-methylene-9-(2-trimethylsilanyl-ethoxymethoxy)-undeca-2,7-dienoic acid ethyl ester

(2R,4S)-4-[(2E,7E)-(4S,9S)-4,8-Dimethyl-6-methylene-9-(2-trimethylsilanyl-ethoxymethoxy)-undeca-2,7-dienyl]-2-(2,4,6-trimethyl-phenyl)-[1,3]dioxolane-4-carboxylic acid methyl ester

Downstream raw materials:

(11E,16E)-(2R,5S,10S,15S)-10-Ethyl-11,15-dimethyl-13-methylene-2-(2,4,6-trimethyl-phenyl)-1,3,9-trioxa-spiro[4.13]octadeca-11,16-diene-6,8-dione