Technology Process of (1R,2R)-(1,2-dihydroxycyclohexyl)acetonitrile
There total 1 articles about (1R,2R)-(1,2-dihydroxycyclohexyl)acetonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
osmium(VIII) oxide; methanesulfonamide; AD-mix-β;
In
water; tert-butyl alcohol;
at 0 ℃;
for 8h;
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1016/S0957-4166(98)00144-X
- Guidance literature:
-
Multi-step reaction with 5 steps
1: camphorsulfonic acid / tetrahydrofuran / 1.5 h / Ambient temperature
2: DIBAL-H / tetrahydrofuran; hexane / 14 h / Ambient temperature
3: Ph3P / CH2Cl2 / 1 h / Ambient temperature
4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, RT, 3 h
5: 2N aq. HCl / methanol / 4 h / Ambient temperature
With
hydrogenchloride; n-butyllithium; camphor-10-sulfonic acid; diisobutylaluminium hydride; triphenylphosphine;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1016/S0957-4166(98)00144-X
- Guidance literature:
-
Multi-step reaction with 5 steps
1: camphorsulfonic acid / tetrahydrofuran / 1.5 h / Ambient temperature
2: DIBAL-H / tetrahydrofuran; hexane / 14 h / Ambient temperature
3: Zn, Me3Al / tetrahydrofuran / 2 h / -20 - 20 °C
4: 2N aq. HCl / methanol / 4 h / Ambient temperature
5: o-iodoxybenzoic acid / dimethylsulfoxide / 6 h / Ambient temperature
With
hydrogenchloride; camphor-10-sulfonic acid; trimethylaluminum; diisobutylaluminium hydride; zinc; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; methanol; hexane; dimethyl sulfoxide;
DOI:10.1016/S0957-4166(98)00144-X
