N-((R)-(2-chlorophenyl)(7-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dimethoxybenzenesulfonamide

Base Information

Chemical Name:N-((R)-(2-chlorophenyl)(7-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dimethoxybenzenesulfonamide
CAS No.:1402598-90-6
Molecular Formula:C₃₁H₂₆ClF₃N₂O₅S₂
Molecular Weight:663.138
Hs Code.:

N-((R)-(2-chlorophenyl)(7-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dimethoxybenzenesulfonamide

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Chemical Property of N-((R)-(2-chlorophenyl)(7-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dimethoxybenzenesulfonamide

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Technology Process of N-((R)-(2-chlorophenyl)(7-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dimethoxybenzenesulfonamide

There total 7 articles about N-((R)-(2-chlorophenyl)(7-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dimethoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23794-15-2
1-(2-chloropyridin-4-yl)ethan-1-one

: 1402598-90-6
N-((R)-(2-chlorophenyl)(7-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dimethoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: cesium fluoride / 1,2-dimethoxyethane / -78 - 20 °C

1.2: 20 h / 20 °C

2.1: Chiralcel^.(R). OJ- H column / isopropyl alcohol; hexane; carbon dioxide / Resolution of racemate

3.1: XPhos; sodium carbonate monohydrate / bis(η3-allyl-μ-chloropalladium(II)) / 1,4-dioxane; water / 21 h / 20 - 80 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

4.2: -78 °C

5.1: hydrogenchloride / diethyl ether / 6 h / 20 °C

6.1: dmap; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 20 °C

With hydrogenchloride; dmap; n-butyllithium; sodium carbonate monohydrate; N-ethyl-N,N-diisopropylamine; cesium fluoride; XPhos; bis(η3-allyl-μ-chloropalladium(II)); In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; diethyl ether; hexane; carbon dioxide; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1402599-08-9
2-(2-chloro-4-pyridinyl)-1,1,1-trifluoro-2-propanol

: 1402598-90-6
N-((R)-(2-chlorophenyl)(7-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dimethoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: Chiralcel^.(R). OJ- H column / isopropyl alcohol; hexane; carbon dioxide / Resolution of racemate

2.1: XPhos; sodium carbonate monohydrate / bis(η3-allyl-μ-chloropalladium(II)) / 1,4-dioxane; water / 21 h / 20 - 80 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

3.2: -78 °C

4.1: hydrogenchloride / diethyl ether / 6 h / 20 °C

5.1: dmap; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 20 °C

With hydrogenchloride; dmap; n-butyllithium; sodium carbonate monohydrate; N-ethyl-N,N-diisopropylamine; XPhos; bis(η3-allyl-μ-chloropalladium(II)); In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; carbon dioxide; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1402599-12-5
(2S)-2-(2-chloro-4-pyridinyl)-1,1,1-trifluoro-2-propanol

: 1402598-90-6
N-((R)-(2-chlorophenyl)(7-(4-((1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-3,4-dimethoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: XPhos; sodium carbonate monohydrate / bis(η3-allyl-μ-chloropalladium(II)) / 1,4-dioxane; water / 21 h / 20 - 80 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: -78 °C

3.1: hydrogenchloride / diethyl ether / 6 h / 20 °C

4.1: dmap; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 20 °C

With hydrogenchloride; dmap; n-butyllithium; sodium carbonate monohydrate; N-ethyl-N,N-diisopropylamine; XPhos; bis(η3-allyl-μ-chloropalladium(II)); In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; water; N,N-dimethyl-formamide;