C₃₂H₂₅BrN₂O

Base Information

• Chemical Name: C₃₂H₂₅BrN₂O
• CAS No.: 1415011-19-6
• Molecular Formula: C₃₂H₂₅BrN₂O
• Molecular Weight: 533.467
• Mol file: 1415011-19-6.mol

Synonyms:

Chemical Property of C₃₂H₂₅BrN₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₂₅BrN₂O

There total 9 articles about C₃₂H₂₅BrN₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-tert-butyl (3-((6-bromo-2-((4-phenylbut-3-yn-2-yl)oxy)naphthalen-1-yl)ethynyl)pyridin-4-yl)(pent-2-yn-1-yl)carbamate (1415011-18-5) → C32H25BrN2O (1415011-19-6)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1039/c2cc35583c

Reference yield:

6-bromo-naphthalen-2-ol (15231-91-1) → C32H25BrN2O (1415011-19-6)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sulfuric acid; potassium iodide; dihydrogen peroxide / methanol / 4 h

2.1: bis-triphenylphosphine-palladium(II) chloride; diisopropylamine; copper(l) iodide / 48 h / 25 °C

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere

4.1: potassium carbonate / methanol / 1 h / 20 °C

5.1: diisopropylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 0.25 h / 20 °C / Inert atmosphere

5.2: 24.5 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

7.1: triethylamine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylsilyl trifluoromethanesulfonate; di-isopropyl azodicarboxylate; sulfuric acid; dihydrogen peroxide; sodium hydride; potassium carbonate; triethylamine; diisopropylamine; triphenylphosphine; potassium iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 2.1: |Sonogashira Cross-Coupling / 3.1: |Mitsunobu Displacement / 5.1: |Sonogashira Cross-Coupling / 5.2: |Sonogashira Cross-Coupling;

DOI:10.1039/c2cc35583c

Reference yield:

iodobenzene (591-50-4) → C32H25BrN2O (1415011-19-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; diisopropylamine; copper(l) iodide / 2 h / 0 - 20 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere

3.1: potassium carbonate / methanol / 1 h / 20 °C

4.1: diisopropylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 0.25 h / 20 °C / Inert atmosphere

4.2: 24.5 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

6.1: triethylamine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylsilyl trifluoromethanesulfonate; di-isopropyl azodicarboxylate; sodium hydride; potassium carbonate; triethylamine; diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 2.1: |Mitsunobu Displacement / 4.1: |Sonogashira Cross-Coupling / 4.2: |Sonogashira Cross-Coupling;

DOI:10.1039/c2cc35583c

upstream raw materials:

6-bromo-naphthalen-2-ol

6-bromo-1-iodonaphthalen-2-ol

iodobenzene

6-bromo-1-((trimethylsilyl)ethynyl)naphthalen-2-ol

Downstream raw materials:

(S)-3-((6-bromo-2-((4-phenylbut-3-yn-2-yl)oxy)naphthalen-1-yl)ethynyl)-N-methyl-N-(pent-2-yn-1-yl)pyridin-4-amine

Refernces