2-Ethyl-2-hydroxy-3-methyl-4-oxo-N,N'-bis(4-oxocyclohexyl)glutaramid

Base Information

Chemical Name:2-Ethyl-2-hydroxy-3-methyl-4-oxo-N,N'-bis(4-oxocyclohexyl)glutaramid
CAS No.:127686-23-1
Molecular Formula:C₂₀H₃₀N₂O₆
Molecular Weight:394.468
Hs Code.:

Synonyms:

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Chemical Property of 2-Ethyl-2-hydroxy-3-methyl-4-oxo-N,N'-bis(4-oxocyclohexyl)glutaramid

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Technology Process of 2-Ethyl-2-hydroxy-3-methyl-4-oxo-N,N'-bis(4-oxocyclohexyl)glutaramid

There total 7 articles about 2-Ethyl-2-hydroxy-3-methyl-4-oxo-N,N'-bis(4-oxocyclohexyl)glutaramid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 127686-22-0
2-Oxo-N-(4-oxocyclohexyl)butyramid

: 127686-23-1
2-Ethyl-2-hydroxy-3-methyl-4-oxo-N,N'-bis(4-oxocyclohexyl)glutaramid

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 3h; Ambient temperature; also with NaOMe in EtOH;

Reference yield:

: 27514-08-5
N-(4-oxocyclohexyl)acetamide

: 127686-23-1
2-Ethyl-2-hydroxy-3-methyl-4-oxo-N,N'-bis(4-oxocyclohexyl)glutaramid

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / p-Toluolsulfonsaeure / toluene / 4 h / Heating

2: 83 percent / KOH / propan-1-ol / 24 h / Heating

3: 85 percent / N-Ethyl-N'-<3-(dimethylamino)propyl>carbodiimid-hydrochlorid / CH₂Cl₂ / other reagents

4: 84 percent / 15percent HCl / acetone / 20 h / Ambient temperature

5: 71 percent / NaH / tetrahydrofuran / 3 h / Ambient temperature; also with NaOMe in EtOH

With hydrogenchloride; potassium hydroxide; sodium hydride; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; propan-1-ol; dichloromethane; acetone; toluene;

Reference yield:

: 23363-88-4
trans-N-acetyl-4-hydroxycyclohexylamine

: 127686-23-1
2-Ethyl-2-hydroxy-3-methyl-4-oxo-N,N'-bis(4-oxocyclohexyl)glutaramid

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / Jones Reagens / H₂O / 20 °C

2: 80 percent / p-Toluolsulfonsaeure / toluene / 4 h / Heating

3: 83 percent / KOH / propan-1-ol / 24 h / Heating

4: 85 percent / N-Ethyl-N'-<3-(dimethylamino)propyl>carbodiimid-hydrochlorid / CH₂Cl₂ / other reagents

5: 84 percent / 15percent HCl / acetone / 20 h / Ambient temperature

6: 71 percent / NaH / tetrahydrofuran / 3 h / Ambient temperature; also with NaOMe in EtOH

With hydrogenchloride; potassium hydroxide; Jones Reagens; sodium hydride; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; propan-1-ol; dichloromethane; water; acetone; toluene;