{2-tert-butoxycarbonylmethoxy-5-[2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenoxy}-acetic acid tert-butyl ester

Base Information

Chemical Name:{2-tert-butoxycarbonylmethoxy-5-[2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenoxy}-acetic acid tert-butyl ester
CAS No.:220193-62-4
Molecular Formula:C₆₀H₇₁N₅O₁₂
Molecular Weight:1054.25
Hs Code.:

{2-<i>tert</i>-butoxycarbonylmethoxy-5-[2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenoxy}-acetic acid <i>tert</i>-butyl ester

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Chemical Property of {2-tert-butoxycarbonylmethoxy-5-[2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenoxy}-acetic acid tert-butyl ester

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Technology Process of {2-tert-butoxycarbonylmethoxy-5-[2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenoxy}-acetic acid tert-butyl ester

There total 2 articles about {2-tert-butoxycarbonylmethoxy-5-[2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenoxy}-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 220193-51-1
{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexyl}-carbamic acid tert-butyl ester

: 220193-62-4
{2-tert-butoxycarbonylmethoxy-5-[2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenoxy}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: TFA, triethylsilane / 1 h / Ambient temperature

2: 1.) DIPCDI, HOBT*H₂O / 1.) DMF, RT, 10 min, 2.) DMF, RT, overnight

With triethylsilane; 1,3-di-tert-butylcarbodiimide; benzotriazol-1-ol; trifluoroacetic acid;
DOI:10.1021/jm980388x

Reference yield:

: 213757-63-2
(S)-3-(3,4-Bis-tert-butoxycarbonylmethoxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

: 220193-52-2
(2S)-2-amino-N₁-[3-(1-naphthalenyl)propyl]butanediamide

: 220193-62-4
{2-tert-butoxycarbonylmethoxy-5-[2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-phenoxy}-acetic acid tert-butyl ester

Guidance literature:: With 1,3-di-tert-butylcarbodiimide; benzotriazol-1-ol; Yield given; Multistep reaction; 1.) DMF, RT, 10 min, 2.) DMF, RT, overnight;
DOI:10.1021/jm980388x