(2R,3S,4aR,5aS,6aR,7aS,8aR,9aS,10aR,14aS,15aR,17aS,18aR,19aS,20aR,21aS)-3-(benzyloxy)-2-((benzyloxy)methyl)-19a-methylhexacosahydro-2H-pyrano[2''' ',3''' ':5''',6''']pyrano[2''',3''':5'',6'']pyrano[2'',3'':5',6']pyrano[2',3':5,6]pyrano[3,2-b]pyrano[2',3':5,6]pyrano[2,3-f]oxepin

Base Information

• Chemical Name: (2R,3S,4aR,5aS,6aR,7aS,8aR,9aS,10aR,14aS,15aR,17aS,18aR,19aS,20aR,21aS)-3-(benzyloxy)-2-((benzyloxy)methyl)-19a-methylhexacosahydro-2H-pyrano[2''' ',3''' ':5''',6''']pyrano[2''',3''':5'',6'']pyrano[2'',3'':5',6']pyrano[2',3':5,6]pyrano[3,2-b]pyrano[2',3':5,6]pyrano[2,3-f]oxepin
• CAS No.: 1415891-45-0
• Molecular Formula: C₄₃H₅₆O₁₀
• Molecular Weight: 732.912

Synonyms:

Chemical Property of (2R,3S,4aR,5aS,6aR,7aS,8aR,9aS,10aR,14aS,15aR,17aS,18aR,19aS,20aR,21aS)-3-(benzyloxy)-2-((benzyloxy)methyl)-19a-methylhexacosahydro-2H-pyrano[2''' ',3''' ':5''',6''']pyrano[2''',3''':5'',6'']pyrano[2'',3'':5',6']pyrano[2',3':5,6]pyrano[3,2-b]pyrano[2',3':5,6]pyrano[2,3-f]oxepin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S,4aR,5aS,6aR,7aS,8aR,9aS,10aR,14aS,15aR,17aS,18aR,19aS,20aR,21aS)-3-(benzyloxy)-2-((benzyloxy)methyl)-19a-methylhexacosahydro-2H-pyrano[2''' ',3''' ':5''',6''']pyrano[2''',3''':5'',6'']pyrano[2'',3'':5',6']pyrano[2',3':5,6]pyrano[3,2-b]pyrano[2',3':5,6]pyrano[2,3-f]oxepin

There total 11 articles about (2R,3S,4aR,5aS,6aR,7aS,8aR,9aS,10aR,14aS,15aR,17aS,18aR,19aS,20aR,21aS)-3-(benzyloxy)-2-((benzyloxy)methyl)-19a-methylhexacosahydro-2H-pyrano[2''' ',3''' ':5''',6''']pyrano[2''',3''':5'',6'']pyrano[2'',3'':5',6']pyrano[2',3':5,6]pyrano[3,2-b]pyrano[2',3':5,6]pyrano[2,3-f]oxepin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S,4aR,5aS,6aR,10aS,11aR,13aS)-3-(benzyloxy)-2-((benzyloxy)methyl)-11a-methoxytetradecahydro-2H-pyrano[3,2-b]pyrano[2',3':5,6]pyrano[2,3-f]oxepine (1415891-57-4) → (2R,3S,4aR,5aS,6aR,7aS,8aR,9aS,10aR,14aS,15aR,17aS,18aR,19aS,20aR,21aS)-3-(benzyloxy)-2-((benzyloxy)methyl)-19a-methylhexacosahydro-2H-pyrano[2''' ',3''' ':5''',6''']pyrano[2''',3''':5'',6'']pyrano[2'',3'':5',6']pyrano[2',3':5,6]pyrano[3,2-b]pyrano[2',3':5,6]pyrano[2,3-f]oxepin (1415891-45-0)

Guidance literature:

Multi-step reaction with 13 steps

1: trimethylsilyl trifluoromethanesulfonate; triethylsilane / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2: hydrogen; 10 wt% Pd(OH)2 on carbon / ethyl acetate / 18 h / 20 °C

3: 2,6-dimethylpyridine / tetrahydrofuran / 0.5 h / -80 °C / Inert atmosphere

4: tetrahydrofuran / 0.67 h / -80 °C / Inert atmosphere

5: n-butyllithium; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran; hexane / -100 °C / Inert atmosphere

6: toluene-4-sulfonic acid / dichloromethane; methanol / 1 h / 20 °C / Inert atmosphere

7: magnesium bromide diethyl etherate; lithium bromide / dichloromethane / 2.5 h / -15 - -5 °C

8: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 20 °C

9: toluene-4-sulfonic acid / methanol; 1,2-dichloro-ethane / 15 h / 80 °C / Inert atmosphere

10: flash chromatography

11: zinc trifluoromethanesulfonate / dichloromethane; nitromethane / 12 h / 20 °C / Inert atmosphere

12: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

13: dichloromethane; n-heptane / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; triethylsilane; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; 10 wt% Pd(OH)2 on carbon; hydrogen; magnesium bromide diethyl etherate; zinc trifluoromethanesulfonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; lithium bromide; In tetrahydrofuran; methanol; nitromethane; hexane; n-heptane; dichloromethane; ethyl acetate; 1,2-dichloro-ethane;

DOI:10.1021/jo302267f

Reference yield:

3-((2S,3R,4aS,6R,7S,8aR)-7-(benzyloxy)-6-((benzyloxy)methyl)-3-(t-butyldimethylsiloxy)octahydropyrano[3,2-b]pyran-2-yl)prop-1-en-1-yl phenyl sulfone → (2R,3S,4aR,5aS,6aR,7aS,8aR,9aS,10aR,14aS,15aR,17aS,18aR,19aS,20aR,21aS)-3-(benzyloxy)-2-((benzyloxy)methyl)-19a-methylhexacosahydro-2H-pyrano[2''' ',3''' ':5''',6''']pyrano[2''',3''':5'',6'']pyrano[2'',3'':5',6']pyrano[2',3':5,6]pyrano[3,2-b]pyrano[2',3':5,6]pyrano[2,3-f]oxepin (1415891-45-0)

Guidance literature:

Multi-step reaction with 10 steps

1: potassium tert-butylate; tert.-butylhydroperoxide / tetrahydrofuran / -78 - -25 °C / Inert atmosphere

2: n-butyllithium; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran; hexane / -100 °C / Inert atmosphere

3: toluene-4-sulfonic acid / dichloromethane; methanol / 1 h / 20 °C / Inert atmosphere

4: magnesium bromide diethyl etherate; lithium bromide / dichloromethane / 2.5 h / -15 - -5 °C

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 20 °C

6: toluene-4-sulfonic acid / methanol; 1,2-dichloro-ethane / 15 h / 80 °C / Inert atmosphere

7: flash chromatography

8: zinc trifluoromethanesulfonate / dichloromethane; nitromethane / 12 h / 20 °C / Inert atmosphere

9: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

10: dichloromethane; n-heptane / 0 - 20 °C / Inert atmosphere

With tert.-butylhydroperoxide; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; potassium tert-butylate; magnesium bromide diethyl etherate; zinc trifluoromethanesulfonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; lithium bromide; In tetrahydrofuran; methanol; nitromethane; hexane; n-heptane; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1021/jo302267f

Reference yield:

C17H25F3O8S → (2R,3S,4aR,5aS,6aR,7aS,8aR,9aS,10aR,14aS,15aR,17aS,18aR,19aS,20aR,21aS)-3-(benzyloxy)-2-((benzyloxy)methyl)-19a-methylhexacosahydro-2H-pyrano[2''' ',3''' ':5''',6''']pyrano[2''',3''':5'',6'']pyrano[2'',3'':5',6']pyrano[2',3':5,6]pyrano[3,2-b]pyrano[2',3':5,6]pyrano[2,3-f]oxepin (1415891-45-0)

Guidance literature:

Multi-step reaction with 10 steps

1: tetrahydrofuran / 0.67 h / -80 °C / Inert atmosphere

2: n-butyllithium; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran; hexane / -100 °C / Inert atmosphere

3: toluene-4-sulfonic acid / dichloromethane; methanol / 1 h / 20 °C / Inert atmosphere

4: magnesium bromide diethyl etherate; lithium bromide / dichloromethane / 2.5 h / -15 - -5 °C

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 20 °C

6: toluene-4-sulfonic acid / methanol; 1,2-dichloro-ethane / 15 h / 80 °C / Inert atmosphere

7: flash chromatography

8: zinc trifluoromethanesulfonate / dichloromethane; nitromethane / 12 h / 20 °C / Inert atmosphere

9: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

10: dichloromethane; n-heptane / 0 - 20 °C / Inert atmosphere

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; magnesium bromide diethyl etherate; zinc trifluoromethanesulfonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; lithium bromide; In tetrahydrofuran; methanol; nitromethane; hexane; n-heptane; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1021/jo302267f

upstream raw materials:

(2S,4aS,6R,7S,8aR)-7-(benzyloxy)-6-((benzyloxy)methyl)-2-(((2R,3S)-3-((tert-butyldimethylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methyl)hexahydropyrano[3,2-b]pyran-3(2H)-one

(2R,3S,4aR,5aS,6aR,10aS,11aR,13aS)-3-(benzyloxy)-2-((benzyloxy)methyl)-11a-methoxytetradecahydro-2H-pyrano[3,2-b]pyrano[2',3':5,6]pyrano[2,3-f]oxepine

3-((2S,3R,4aS,6R,7S,8aR)-7-(benzyloxy)-6-((benzyloxy)methyl)-3-(t-butyldimethylsiloxy)octahydropyrano[3,2-b]pyran-2-yl)-1,2-epoxypropan-1-yl phenyl sulfone

C₆₀H₈₈O₁₃SSi₂

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1415891-45-0 (2R,3S,4aR,5aS,6aR,7aS,8aR,9aS,10aR,14aS,15aR,17aS,18aR,19aS,20aR,21aS)-3-(benzyloxy)-2-((benzyloxy)methyl)-19a-methylhexacosahydro-2H-pyrano[2''' ',3''' ':5''',6''']pyrano[2''',3''':5'',6'']pyrano[2'',3'':5',6']pyrano[2',3':5,6]pyrano[3,2-b]pyrano[2',3':5,6]pyrano[2,3-f]oxepin

Send

Send

Metric Ton KG G Pound L ML

Send

Send