D-Phenylalanine, N-acetyl-a-methyl-, ethyl ester

Base Information

Chemical Name:D-Phenylalanine, N-acetyl-a-methyl-, ethyl ester
CAS No.:116562-88-0
Molecular Formula:C14H19NO3
Molecular Weight:249.31
Hs Code.:

Synonyms:

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Chemical Property of D-Phenylalanine, N-acetyl-a-methyl-, ethyl ester

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of D-Phenylalanine, N-acetyl-a-methyl-, ethyl ester

There total 5 articles about D-Phenylalanine, N-acetyl-a-methyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 89656-86-0
ethyl (S)-2-benzyl-2-methyl-3-oxobutyrate

: 116562-88-0
(R)-N-acetyl-α-methylphenylalanine ethyl ester

Guidance literature:: With sodium azide; methanesulfonic acid; In chloroform; for 1h; Heating;
DOI:10.1016/S0040-4039(00)80107-0

Reference yield:

: 609-14-3
2-acetylpropanoic acid ethyl ester

: 116562-88-0
(R)-N-acetyl-α-methylphenylalanine ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 81 percent / p-toluenesulfonic acid monohydrate / benzene / 10 h / Heating

2.1: LDA; HMPA / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: tetrahydrofuran / 5 h / -78 - -40 °C

3.1: 73 percent / BF₃-OEt₂ / ethanol; H₂O / 3 h / 20 °C

4.1: 95 percent / NaN₃; methansulfonic acid / CHCl₃ / 6 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium azide; methanesulfonic acid; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; chloroform; water; benzene; 4.1: Schmidt rearrangement;
DOI:10.1021/jo001423m

Reference yield:

: 340039-86-3
ethyl (2RS)-3,3-<(S,S)-cyclohexane-1,2-dioxy>-2-methylbutanoate

: 116562-88-0
(R)-N-acetyl-α-methylphenylalanine ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA; HMPA / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: tetrahydrofuran / 5 h / -78 - -40 °C

2.1: 73 percent / BF₃-OEt₂ / ethanol; H₂O / 3 h / 20 °C

3.1: 95 percent / NaN₃; methansulfonic acid / CHCl₃ / 6 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium azide; methanesulfonic acid; boron trifluoride diethyl etherate; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; chloroform; water; 3.1: Schmidt rearrangement;
DOI:10.1021/jo001423m