Methyl 2-chloro-4-hydroxy-6-methylbenzoate

Base Information

Chemical Name:Methyl 2-chloro-4-hydroxy-6-methylbenzoate
CAS No.:116621-21-7
Molecular Formula:C9H9ClO3
Molecular Weight:200.622
Hs Code.:
DSSTox Substance ID:DTXSID70568400
Wikidata:Q82454640
Mol file:116621-21-7.mol

Synonyms:116621-21-7;Methyl 2-chloro-4-hydroxy-6-methylbenzoate;SCHEMBL20503232;DTXSID70568400

Suppliers and Price of Methyl 2-chloro-4-hydroxy-6-methylbenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Methyl 2-chloro-4-hydroxy-6-methylbenzoate

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:200.0240218
Heavy Atom Count:13
Complexity:195

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=CC(=C1C(=O)OC)Cl)O

Technology Process of Methyl 2-chloro-4-hydroxy-6-methylbenzoate

There total 7 articles about Methyl 2-chloro-4-hydroxy-6-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: methyl 2-chloro-6-methyl-4-(4,4,5 ,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: 116621-21-7
methyl 2-chloro-4-hydroxy-6-methylbenzoate

Guidance literature:: With potassium peroxymonosulfate sulfate; water; In acetone; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1055/s-0037-1610538

Reference yield: 78.0%

: 116621-20-6
methyl 4-amino-2-chloro-6-methylbenzoate

: 116621-21-7
methyl 2-chloro-4-hydroxy-6-methylbenzoate

Guidance literature:: With sulfuric acid; sodium nitrite; at 70 - 80 ℃; for 1.5h;
DOI:10.1248/cpb.39.2400

Reference yield:

: 89894-12-2
2-chloro-6-methyl-4-nitrobenzoic acid

: 116621-21-7
methyl 2-chloro-4-hydroxy-6-methylbenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 2 h / Heating

2: 4.5 h / Heating

3: 97.4 percent / H₂ / PtO₂ / ethyl acetate / 760 Torr

4: 78 percent / NaNO₂, 10percent aq. H₂SO₄ / 1.5 h / 70 - 80 °C

With thionyl chloride; sulfuric acid; hydrogen; sodium nitrite; platinum(IV) oxide; In ethyl acetate;
DOI:10.1248/cpb.39.2400