tert-butyl (R)-1-formyl-3-methylbutylcarbamate

Base Information

• Chemical Name: tert-butyl (R)-1-formyl-3-methylbutylcarbamate
• CAS No.: 116662-96-5
• Molecular Formula: C11H21NO3
• Molecular Weight: 215.28900
• Mol file: 116662-96-5.mol

Synonyms:(R)-TERT-BUTYL 4-METHYL-1-OXOPENTAN-2-YLCARBAMATE;D-Boc-leucinal;(R)-tert-butyl (4-methyl-1-oxopentan-2-yl)carbamate;(R)-tert-butyl 4-methyl-1-oxopentan-2-yl carbamate;(2R)-2-(tert-butoxycarbonylamino)-4-methylpentylaldehyde;(2R)-2-(1,1-dimethylethoxycarbonylamino)-4-methylpentanal;(R)-2-(N-tert-butyloxycarbonyl)amino-4-methylpentanal;

Chemical Property of tert-butyl (R)-1-formyl-3-methylbutylcarbamate

Chemical Property:

• PSA: 55.40000
• LogP: 2.51560

Purity/Quality:

97% ^*data from raw suppliers

TERT-BUTYL (R)-1-FORMYL-3-METHYLBUTYLCARBAMATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl (R)-1-formyl-3-methylbutylcarbamate

There total 9 articles about tert-butyl (R)-1-formyl-3-methylbutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl [(2R)-1-hydroxy-4-methylpentan-2-yl]carbamate (106930-51-2) → (2R)-2-(1,1-dimethylethoxycarbonylamino)-4-methylpentanal (116662-96-5)

Guidance literature:

With Dess-Martin periodane; tert-butyl alcohol; In dichloromethane; Ambient temperature;

DOI:10.1135/cccc19950693

Reference yield: 72.0%

(R)-Nα-(tert-butoxycarbonyl)-N-methoxy-N-methylleucinamide (129603-01-6) → (2R)-2-(1,1-dimethylethoxycarbonylamino)-4-methylpentanal (116662-96-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; or in diethyl ether;

DOI:10.1055/s-1990-26900

Reference yield: 67.0%

(4S,5S)-2-<(R)-1-(1,1-dimethylethoxycarbonylamino)-3-methylbutyl>-1,3-dimethyl-4,5-diphenylimidazolidine → (2R)-2-(1,1-dimethylethoxycarbonylamino)-4-methylpentanal (116662-96-5)

Guidance literature:

With hydrogenchloride; In diethyl ether; Ambient temperature;

DOI:10.1055/s-1995-4042

upstream raw materials:

(R)-N^α-(tert-butoxycarbonyl)-N-methoxy-N-methylleucinamide

tert-butyl [(2R)-1-hydroxy-4-methylpentan-2-yl]carbamate

methyl (2R)-2-(tert-butoxycarbonylamino)-4-methylpentanoate

N-(tert-butoxycarbonyl)-L-leucine-N'-methoxy-N'-methylamide