L-prolyl-N^ε-phenylacetyl-L-lysyl-glycine hydrobromide

Base Information

Chemical Name:L-prolyl-N^ε-phenylacetyl-L-lysyl-glycine hydrobromide
CAS No.:80442-90-6
Molecular Formula:BrH*C₂₁H₃₁N₅O₄
Molecular Weight:498.42
Hs Code.:

L-prolyl-N<sup>ε</sup>-phenylacetyl-L-lysyl-glycine hydrobromide

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Chemical Property of L-prolyl-N^ε-phenylacetyl-L-lysyl-glycine hydrobromide

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Technology Process of L-prolyl-N^ε-phenylacetyl-L-lysyl-glycine hydrobromide

There total 8 articles about L-prolyl-N^ε-phenylacetyl-L-lysyl-glycine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80442-89-3
N^α-benzyloxycarbonyl-L-prolyl-N^ε-phenylacetyl-L-lysyl-glycine amide

: 80442-90-6
L-prolyl-N^ε-phenylacetyl-L-lysyl-glycine hydrobromide

Guidance literature:: With hydrogen bromide; In acetic acid; for 0.5h; Ambient temperature;

Reference yield:

: 18836-42-5
N^ε-phenylacetyl-L-lysine

: 80442-90-6
L-prolyl-N^ε-phenylacetyl-L-lysyl-glycine hydrobromide

Guidance literature:: Multi-step reaction with 5 steps

1: 6.1 g / 1M-aq. NaOH / 1 h

2: 1) N-ethylpiperidine, 1-hydroxybenzotriazole; 2) dicyclohexylcarbodiimide / 1) DMF; 2) 1 h at -5 deg C, then 16 h at room temp.

3: 4M hydrogen bromide / acetic acid / 0.5 h / Ambient temperature

4: 1) N-ethylpiperidine, 1-hydroxybenzotriazole; 2) dicyclohexylcarbodiimide / 1) DMF, pH: 10; 2) 1 h at -10 deg C, then 15 h at room temp.

5: 4M hydrogen bromide / acetic acid / 0.5 h / Ambient temperature

With 1-ethyl-piperidine; sodium hydroxide; hydrogen bromide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In acetic acid;

Reference yield:

: 657-27-2,10098-89-2,26124-78-7
L-Lysine hydrochloride

: 80442-90-6
L-prolyl-N^ε-phenylacetyl-L-lysyl-glycine hydrobromide

Guidance literature:: Multi-step reaction with 6 steps

1: 1) copper carbonate dihydroxide; 2) 2M-aq. NaOH ; 3) hydrogen sulfide / 1) water, reflux, 2 h; 2) pH: 10, 30 min; 3) aq. hydrochloric acid (pH: 2), 90 deg C, 1 h

2: 6.1 g / 1M-aq. NaOH / 1 h

3: 1) N-ethylpiperidine, 1-hydroxybenzotriazole; 2) dicyclohexylcarbodiimide / 1) DMF; 2) 1 h at -5 deg C, then 16 h at room temp.

4: 4M hydrogen bromide / acetic acid / 0.5 h / Ambient temperature

5: 1) N-ethylpiperidine, 1-hydroxybenzotriazole; 2) dicyclohexylcarbodiimide / 1) DMF, pH: 10; 2) 1 h at -10 deg C, then 15 h at room temp.

6: 4M hydrogen bromide / acetic acid / 0.5 h / Ambient temperature

With 1-ethyl-piperidine; sodium hydroxide; copper carbonate dihydroxide; hydrogen sulfide; hydrogen bromide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In acetic acid;