methyl 3-<2-(2-octan-t-6-yl>ethyl)-1,3-dithiolan-2-yl>propionate

Base Information

• Chemical Name: methyl 3-<2-(2-octan-t-6-yl>ethyl)-1,3-dithiolan-2-yl>propionate
• CAS No.: 118908-18-2
• Molecular Formula: C₂₉H₃₂O₆S₂
• Molecular Weight: 540.701
• Mol file: 118908-18-2.mol

Synonyms:

Chemical Property of methyl 3-<2-(2-octan-t-6-yl>ethyl)-1,3-dithiolan-2-yl>propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-<2-(2-octan-t-6-yl>ethyl)-1,3-dithiolan-2-yl>propionate

There total 4 articles about methyl 3-<2-(2-octan-t-6-yl>ethyl)-1,3-dithiolan-2-yl>propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

ethane-1,2-dithiol (540-63-6) + Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-(5-methoxycarbonyl-3-oxo-pentyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester (118908-17-1) → methyl 3-<2-(2-octan-t-6-yl>ethyl)-1,3-dithiolan-2-yl>propionate (118908-18-2)

Guidance literature:

With zinc trifluoromethanesulfonate; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1039/P19880002821

Reference yield:

(-)-Corey lactone 5-(4-phenylbenzoate) (31752-99-5) → methyl 3-<2-(2-octan-t-6-yl>ethyl)-1,3-dithiolan-2-yl>propionate (118908-18-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) dicyclohexylcarbodi-imide; 2.) dichloroacetic acid; 3.) oxalic acid / 1.) benzene, DMSO, 5 min; 2.) 20 min, 3.) methanol, 10 min

2: tetrahydrofuran / 3 h / Ambient temperature

3: 90 percent / H₂ / palladium-carbon / ethyl acetate / 4 h / Ambient temperature

4: 82 percent / zinc triflate / CH₂Cl₂ / 2 h / Ambient temperature

With dichloro-acetic acid; hydrogen; oxalic acid; zinc trifluoromethanesulfonate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;

DOI:10.1039/P19880002821

Reference yield:

Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-((E)-5-methoxycarbonyl-3-oxo-pent-1-enyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester (118908-16-0) → methyl 3-<2-(2-octan-t-6-yl>ethyl)-1,3-dithiolan-2-yl>propionate (118908-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / H₂ / palladium-carbon / ethyl acetate / 4 h / Ambient temperature

2: 82 percent / zinc triflate / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogen; zinc trifluoromethanesulfonate; palladium on activated charcoal; In dichloromethane; ethyl acetate;

DOI:10.1039/P19880002821

upstream raw materials:

ethane-1,2-dithiol

Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-(5-methoxycarbonyl-3-oxo-pentyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

(-)-Corey lactone 5-(4-phenylbenzoate)

Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-((E)-5-methoxycarbonyl-3-oxo-pent-1-enyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

Downstream raw materials:

(Z)-9α-11β-dihydroxy-15-oxo-2,3,18.19-tetranorprost-5-ene-1,20-dioic acid

6-[(1R,2R,3S,5S)-2-((E)-4-Carboxy-but-2-enyl)-3,5-dihydroxy-cyclopentyl]-4-oxo-hexanoic acid