N^α-t-butyloxycarbonyl-N-2-chlorobenzyloxycarbonyl-L-lysine dicyclohexylammonium salt

Base Information

• Chemical Name: N^α-t-butyloxycarbonyl-N-2-chlorobenzyloxycarbonyl-L-lysine dicyclohexylammonium salt
• CAS No.: 73977-22-7
• Molecular Formula: C₁₂H₂₃N*C₁₉H₂₇ClN₂O₆
• Molecular Weight: 596.207
• Mol file: 73977-22-7.mol

Synonyms:

Chemical Property of N^α-t-butyloxycarbonyl-N-2-chlorobenzyloxycarbonyl-L-lysine dicyclohexylammonium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-t-butyloxycarbonyl-N-2-chlorobenzyloxycarbonyl-L-lysine dicyclohexylammonium salt

There total 4 articles about N^α-t-butyloxycarbonyl-N-2-chlorobenzyloxycarbonyl-L-lysine dicyclohexylammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Chlorobenzyl alcohol (17849-38-6) → Nα-t-butyloxycarbonyl-N-2-chlorobenzyloxycarbonyl-L-lysine dicyclohexylammonium salt (73977-22-7)

Guidance literature:

Multi-step reaction with 4 steps

1: benzene / 60 h / Ambient temperature

3: 6M NaOH / dioxane / 40 °C

4: diethyl ether; petroleum ether

With sodium hydroxide; In 1,4-dioxane; diethyl ether; Petroleum ether; benzene;

Reference yield:

2-chlorobenzyl chloroformate (39545-31-8) → Nα-t-butyloxycarbonyl-N-2-chlorobenzyloxycarbonyl-L-lysine dicyclohexylammonium salt (73977-22-7)

Guidance literature:

Multi-step reaction with 3 steps

2: 6M NaOH / dioxane / 40 °C

3: diethyl ether; petroleum ether

With sodium hydroxide; In 1,4-dioxane; diethyl ether; Petroleum ether;

Reference yield:

Nε-(2-Chlorophenylmethoxycarbonyl)-(S)-lysine (42390-97-6,201014-19-9) → Nα-t-butyloxycarbonyl-N-2-chlorobenzyloxycarbonyl-L-lysine dicyclohexylammonium salt (73977-22-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 6M NaOH / dioxane / 40 °C

2: diethyl ether; petroleum ether

With sodium hydroxide; In 1,4-dioxane; diethyl ether; Petroleum ether;

upstream raw materials:

Boc-(S)-Lys(2-Cl-Z)-OH

N-cyclohexyl-cyclohexanamine

2-Chlorobenzyl alcohol

2-chlorobenzyl chloroformate

Refernces