1-bromo-1-(4'-bromophenyl)-4,5α-epoxy-6α,14-etheno-3,6-dimethoxy-17-methyl-2',5',7β,8β-tetrahydro-1'H-14α-pyrrolo[3',4':7,8]morphinan-2',5'-dione

Base Information

• Chemical Name: 1-bromo-1-(4'-bromophenyl)-4,5α-epoxy-6α,14-etheno-3,6-dimethoxy-17-methyl-2',5',7β,8β-tetrahydro-1'H-14α-pyrrolo[3',4':7,8]morphinan-2',5'-dione
• CAS No.: 1008355-58-5
• Molecular Formula: C₂₉H₂₆Br₂N₂O₅
• Molecular Weight: 642.344
• Mol file: 1008355-58-5.mol

Synonyms:

Chemical Property of 1-bromo-1-(4'-bromophenyl)-4,5α-epoxy-6α,14-etheno-3,6-dimethoxy-17-methyl-2',5',7β,8β-tetrahydro-1'H-14α-pyrrolo[3',4':7,8]morphinan-2',5'-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-bromo-1-(4'-bromophenyl)-4,5α-epoxy-6α,14-etheno-3,6-dimethoxy-17-methyl-2',5',7β,8β-tetrahydro-1'H-14α-pyrrolo[3',4':7,8]morphinan-2',5'-dione

There total 2 articles about 1-bromo-1-(4'-bromophenyl)-4,5α-epoxy-6α,14-etheno-3,6-dimethoxy-17-methyl-2',5',7β,8β-tetrahydro-1'H-14α-pyrrolo[3',4':7,8]morphinan-2',5'-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-1-(4'-bromophenyl)-4,5α-epoxy-6α,14-etheno-3,6-dimethoxy-17-methyl-2',5',7β,8β-tetrahydro-1'H-14α-pyrrolo[3',4':7,8]morphinan-2',5'-dione hydrobromide → 1-bromo-1-(4'-bromophenyl)-4,5α-epoxy-6α,14-etheno-3,6-dimethoxy-17-methyl-2',5',7β,8β-tetrahydro-1'H-14α-pyrrolo[3',4':7,8]morphinan-2',5'-dione (1008355-58-5)

Guidance literature:

With sodium carbonate;

DOI:10.1134/S1070428007040070

Reference yield:

C29H27BrN2O5 (766550-46-3) → 1-bromo-1-(4'-bromophenyl)-4,5α-epoxy-6α,14-etheno-3,6-dimethoxy-17-methyl-2',5',7β,8β-tetrahydro-1'H-14α-pyrrolo[3',4':7,8]morphinan-2',5'-dione (1008355-58-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 73.4 percent / bromine; formic acid / 1.5 h / 0 - 5 °C

2: 0.36 g / aq. sodium carbonate

With formic acid; bromine; sodium carbonate;

DOI:10.1134/S1070428007040070

Reference yield: 5.0%

1-bromo-1-(4'-bromophenyl)-4,5α-epoxy-6α,14-etheno-3,6-dimethoxy-17-methyl-2',5',7β,8β-tetrahydro-1'H-14α-pyrrolo[3',4':7,8]morphinan-2',5'-dione (1008355-58-5) + ethyl acrylate (140-88-5,9003-32-1) → ethyl (E)-3-[1'-(4-bromophenyl)-4,5α-epoxy-6α,14-etheno-3,6-dimethoxy-17-methyl-2',5'-dioxo-2',5',7β,8β-tetrahydro-1'H-14α-pyrrolo[3',4':7,8]morphinan-1-yl]prop-2-enoate + ethyl (E)-3-[4-(1-bromo-4,5α-epoxy-6α,14-etheno-3,6-dimethoxy-17-methyl-2',5'-dioxo-2',5',7β,8β-tetrahydro-1'H-14α-pyrrolo[3',4':7,8]morphinan-1-yl)phenyl]prop-2-enoate

Guidance literature:

With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide; at 150 ℃;

DOI:10.1134/S1070428007040070

upstream raw materials:

C₂₉H₂₇BrN₂O₅