(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-pentanedioic acid 5-amide 1-({(S)-1-[(S)-1-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-amide)

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Chemical Name:(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-pentanedioic acid 5-amide 1-({(S)-1-[(S)-1-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-amide)
CAS No.:81682-75-9
Molecular Formula:C₄₁H₆₁N₉O₈S
Molecular Weight:840.057
Hs Code.:

(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-pentanedioic acid 5-amide 1-({(S)-1-[(S)-1-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-amide)

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Chemical Property of (S)-2-((S)-2-Amino-3-methyl-butyrylamino)-pentanedioic acid 5-amide 1-({(S)-1-[(S)-1-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-amide)

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Technology Process of (S)-2-((S)-2-Amino-3-methyl-butyrylamino)-pentanedioic acid 5-amide 1-({(S)-1-[(S)-1-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-amide)

There total 6 articles about (S)-2-((S)-2-Amino-3-methyl-butyrylamino)-pentanedioic acid 5-amide 1-({(S)-1-[(S)-1-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-amide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 81682-75-9
(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-pentanedioic acid 5-amide 1-({(S)-1-[(S)-1-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-amide)

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / N-methylmorpholine, 1-hydroxybenztriazole, dicyclohexylcarbodiimide / dimethylformamide / 2 h, 0 deg C; 24 h, room temp.

2: 97 percent / hydrogen / 10 percent Pd/C / dimethylformamide; H₂O

3: 78 percent / 1-hydroxybenztriazol, dicyclohexylcarbodiimide N-methylmorpholine / dimethylformamide / 0 deg C, 2 h then room temp., 24 h

4: 1.75N HCl / acetic acid / 1 h

With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: Boc-Val-Gln-Phe-Phe-Gly-OBzl

: 81682-75-9
(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-pentanedioic acid 5-amide 1-({(S)-1-[(S)-1-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-amide)

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / hydrogen / 10 percent Pd/C / dimethylformamide; H₂O

2: 78 percent / 1-hydroxybenztriazol, dicyclohexylcarbodiimide N-methylmorpholine / dimethylformamide / 0 deg C, 2 h then room temp., 24 h

3: 1.75N HCl / acetic acid / 1 h

With hydrogenchloride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In water; acetic acid; N,N-dimethyl-formamide;