(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2<<(2S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ether

Base Information

Chemical Name:(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2<<(2S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ether
CAS No.:137282-00-9
Molecular Formula:C₃₅H₄₇N₃O₆
Molecular Weight:605.775
Hs Code.:

(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2<<(2S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ether

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Chemical Property of (3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2<<(2S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ether

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Technology Process of (3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2<<(2S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ether

There total 3 articles about (3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2<<(2S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 137282-00-9,139238-61-2,139238-64-5
(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2<<(2S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) NaCNBH₃ / 1.) MeOH, 5 min, 2.) MeOH, reflux, overnight

2: 1.) 1-hydroxybenzotriazole (HOBt), 2.) 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate (CMC) / 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₂Cl₂, RT, overnight

With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; sodium cyanoborohydride; benzotriazol-1-ol;
DOI:10.1021/jm00083a005

Reference yield:

: 4122-56-9
methyl o-formylbenzoate

: 137282-00-9,139238-61-2,139238-64-5
(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2<<(2S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) NaCNBH₃ / 1.) MeOH, 5 min, 2.) MeOH, reflux, overnight

2: 1.) 1-hydroxybenzotriazole (HOBt), 2.) 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate (CMC) / 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₂Cl₂, RT, overnight

With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; sodium cyanoborohydride; benzotriazol-1-ol;
DOI:10.1021/jm00083a005

Reference yield:

: 105776-76-9
(S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionic acid

: 137282-25-8
(S)-3-((S)-2-Amino-pentanoylamino)-4-cyclohexyl-2-hydroxy-butyric acid isopropyl ester; compound with trifluoro-acetic acid

: 137282-00-9,139238-61-2,139238-64-5
(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-2<<(2S)-2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ether

Guidance literature:: With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; benzotriazol-1-ol; Yield given. Multistep reaction; 1.) CH₂Cl₂, 0 deg C, 10 min, 2.) CH₂Cl₂, RT, overnight;
DOI:10.1021/jm00083a005