E-Combretastatin A-4

Base Information Edit

Chemical Name:E-Combretastatin A-4
CAS No.:117048-62-1
Molecular Formula:C₁₈H₂₀O₅
Molecular Weight:316.354
Hs Code.:
NSC Number:609397
UNII:ND4BUQ9WHL
Nikkaji Number:J421.339D,J2.457.974C
ChEMBL ID:CHEMBL36455
Mol file:117048-62-1.mol

Synonyms:ND4BUQ9WHL;Trans-Combretastatin A-4;Combretastatin A4, trans-;NSC-609397;E-Combretastatin A-4;UNII-ND4BUQ9WHL;CHEMBL36455;NSC609397;NSC613729;2-methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol;2-methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol;2-Methoxy-5-((1E)-2-(3,4,5-trimethoxyphenyl)ethenyl)phenol;Phenol, 2-methoxy-5-((1E)-2-(3,4,5-trimethoxyphenyl)ethenyl)-;117048-62-1;2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]phenol;2-Methoxy-5-[(1E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol;Phenol, 2-methoxy-5-[(1E)-2-(3,4,5-trimethoxyphenyl)ethenyl]-;2-methoxy-5-(3,4,5-trimethoxystyryl)phenol;trans-(E)-Combretastatin;2-methoxy-5-(2-(3,4,5-trimethoxyphenyl)ethenyl)phenol;2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol;From Combretum caffrum plant;SCHEMBL18946;SCHEMBL9707931;HVXBOLULGPECHP-AATRIKPKSA-N;BDBM50009561;CCG-35662;CCG-36400;AKOS015915109;ND-2980;LS-186888;LS-187542;B817373K328;3',4,4',5'-Tetramethoxy-cis-stilbene-3-ol;(E)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenol;A803704;J-003498;2-Methoxy-5-(2-(3,4,5-trimethoxyphenyl)vinyl)phenol;2-Methoxy-5-[(E)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol;trans-2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol

Suppliers and Price of E-Combretastatin A-4

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of E-Combretastatin A-4 Edit

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:316.13107373
Heavy Atom Count:23
Complexity:358

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)O
Isomeric SMILES:COC1=C(C=C(C=C1)/C=C/C2=CC(=C(C(=C2)OC)OC)OC)O

Technology Process of E-Combretastatin A-4

There total 135 articles about E-Combretastatin A-4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.35%

: C₃₇H₃₄O₅

: 117048-62-1,117048-59-6
combrestatin A₄

Guidance literature:: With hydrogenchloride; In ethanol; water; at 20 ℃; for 3h;

Reference yield: 95.0%

: 185698-55-9
2-(3-hydroxy-4-methoxyphenyl)-1-(3',4',5'-trimethoxyphenyl)ethyne

: 117048-62-1,117048-59-6
combrestatin A₄

Guidance literature:: With ethanol; (NCP)IrHCl; tert-butylamine; at 75 ℃; for 24h; stereoselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1021/jacs.1c01472