(-)-2-<<2-(camphanoylamino)ethoxy>methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine

Base Information

• Chemical Name: (-)-2-<<2-(camphanoylamino)ethoxy>methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine
• CAS No.: 143191-86-0
• Molecular Formula: C₃₀H₃₇ClN₂O₈
• Molecular Weight: 589.085
• Mol file: 143191-86-0.mol

Synonyms:

Chemical Property of (-)-2-<<2-(camphanoylamino)ethoxy>methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-2-<<2-(camphanoylamino)ethoxy>methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine

There total 6 articles about (-)-2-<<2-(camphanoylamino)ethoxy>methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (103069-49-4) → (-)-2-<<2-(camphanoylamino)ethoxy>methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine (143191-86-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) carbonyldiimidazole

2: ethanol / 1 h / Heating

3: 6percent nickel chloride, sodium borohydride / ethanol / Ambient temperature

4: pyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; sodium tetrahydroborate; 1,1'-carbonyldiimidazole; nickel dichloride; In ethanol; dichloromethane;

DOI:10.1021/jm00096a005

Reference yield:

2-<(2-azidoethoxy)methyl>-4(S)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine (125711-60-6) → (-)-2-<<2-(camphanoylamino)ethoxy>methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine (143191-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 6percent nickel chloride, sodium borohydride / ethanol / Ambient temperature

2: pyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; sodium tetrahydroborate; nickel dichloride; In ethanol; dichloromethane;

DOI:10.1021/jm00096a005

Reference yield:

2-<<2-<(tert-butoxycarbonyl)amino>ethoxy>-methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine (143290-24-8) → (-)-2-<<2-(camphanoylamino)ethoxy>methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine (143191-86-0)

Guidance literature:

Multi-step reaction with 3 steps

2: 64 percent / 6.7 M HCl / acetonitrile; dioxane / 1 h

3: pyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; hydrogenchloride; In 1,4-dioxane; dichloromethane; acetonitrile;

DOI:10.1021/jm00096a005

upstream raw materials:

2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

(1S)-(-)-camphanic chloride

2-<(2-azidoethoxy)methyl>-4-(2-chlorophenyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

2-<(2-azidoethoxy)methyl>-4(S)-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-1,4-dihydropyridine