Technology Process of 4-(2-chloro-5-isobutoxy-N-methylbenzamido)-3,5-dimethylbenzoic acid
There total 8 articles about 4-(2-chloro-5-isobutoxy-N-methylbenzamido)-3,5-dimethylbenzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: thionyl chloride / 18 h / 60 °C
2: palladium 10% on activated carbon; hydrogen / ethyl acetate; ethanol / 20 °C
3: potassium carbonate / tetrahydrofuran / 0 - 20 °C
4: sodium hydroxide; water / tetrahydrofuran / 80 °C
5: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C
With
thionyl chloride; palladium 10% on activated carbon; water; hydrogen; sodium hydride; potassium carbonate; sodium hydroxide;
In
tetrahydrofuran; ethanol; ethyl acetate; mineral oil;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hydroxide; water / tetrahydrofuran / 80 °C
2: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C
With
water; sodium hydride; sodium hydroxide;
In
tetrahydrofuran; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: caesium carbonate / acetonitrile / Reflux
2: sodium hydroxide; water / methanol / 4 h / Reflux
3: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 20 °C
4: potassium carbonate / tetrahydrofuran / 0 - 20 °C
5: sodium hydroxide; water / tetrahydrofuran / 80 °C
6: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C
With
oxalyl dichloride; water; sodium hydride; potassium carbonate; caesium carbonate; N,N-dimethyl-formamide; sodium hydroxide;
In
tetrahydrofuran; methanol; acetonitrile; mineral oil;
