Technology Process of 1H-Isoindole, 2,3-dihydro-1,3-bis(phenylmethyl)-, (1R,3R)-
There total 7 articles about 1H-Isoindole, 2,3-dihydro-1,3-bis(phenylmethyl)-, (1R,3R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid; hydrazine hydrate;
In
ethanol;
for 70h;
Heating;
DOI:10.1021/jo00257a041
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 50 percent / BH3*THF / tetrahydrofuran / 14 h / Heating
2: 87 percent / p-toluenesulfonic acid / benzene / Heating
3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) from -100 deg C to -20 deg C
4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) from -100 deg C to -20 deg C
5: 42 percent / p-toluenesulfonic acid, hydrazine hydrate / aq. ethanol / 70 h / Heating
With
n-butyllithium; borane-THF; toluene-4-sulfonic acid; hydrazine hydrate;
In
tetrahydrofuran; ethanol; benzene;
DOI:10.1021/jo00257a041
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 87 percent / p-toluenesulfonic acid / benzene / Heating
2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) from -100 deg C to -20 deg C
3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) from -100 deg C to -20 deg C
4: 42 percent / p-toluenesulfonic acid, hydrazine hydrate / aq. ethanol / 70 h / Heating
With
n-butyllithium; toluene-4-sulfonic acid; hydrazine hydrate;
In
ethanol; benzene;
DOI:10.1021/jo00257a041
