GEN6776

Base Information

• Chemical Name: GEN6776
• CAS No.: 2009273-71-4
• Molecular Formula: C₂₀H₂₀N₄O₂
• Molecular Weight: 348.404
• Mol file: 2009273-71-4.mol

Synonyms:

Chemical Property of GEN6776

Chemical Property:

• Boiling Point: 609.7±55.0 °C(Predicted)
• PKA: 8.14±0.15(Predicted)
• Density: 1.242±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

GNE-6776 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: GNE6776, is a selective USP7 inhibitor.

Technology Process of GEN6776

There total 7 articles about GEN6776 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

[6-(methylcarbamoyl)pyridin-3-yl]boronic acid (1217340-94-7) + 4-(2-amino-5-bromo-4-ethylpyridin-3-yl)phenol → 5-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridyl]-N-methylpyridine-2-carboxamide (2009273-71-4)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 80 ℃; for 16h; Inert atmosphere;

Reference yield:

N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxamide (945863-21-8) + 4-(2-amino-5-bromo-4-ethylpyridin-3-yl)phenol → 5-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridyl]-N-methylpyridine-2-carboxamide (2009273-71-4)

Guidance literature:

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate; In 1,4-dioxane; water; at 80 ℃; for 16h; Inert atmosphere;

DOI:10.1038/nature24006

Reference yield:

4-ethyl-3-(4-methoxyphenyl)pyridin-2-amine → 5-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridyl]-N-methylpyridine-2-carboxamide (2009273-71-4)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide / tetrahydrofuran / 0.25 h / 0 - 20 °C / Inert atmosphere

2: boron tribromide / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

3: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 16 h / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; boron tribromide; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

upstream raw materials:

4-ethylpyridin-2-amine

[6-(methylcarbamoyl)pyridin-3-yl]boronic acid

N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxamide