N₁,N₂-bis((1R,2R)-2-hydroxy-7-phenyl-2,3-dihydro-1H-inden-1-yl)oxalamide

Base Information

Chemical Name:N₁,N₂-bis((1R,2R)-2-hydroxy-7-phenyl-2,3-dihydro-1H-inden-1-yl)oxalamide
CAS No.:1354558-57-8
Molecular Formula:C₃₂H₂₈N₂O₄
Molecular Weight:504.585
Hs Code.:

N<sub>1</sub>,N<sub>2</sub>-bis((1R,2R)-2-hydroxy-7-phenyl-2,3-dihydro-1H-inden-1-yl)oxalamide

Synonyms:

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Chemical Property of N₁,N₂-bis((1R,2R)-2-hydroxy-7-phenyl-2,3-dihydro-1H-inden-1-yl)oxalamide

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Technology Process of N₁,N₂-bis((1R,2R)-2-hydroxy-7-phenyl-2,3-dihydro-1H-inden-1-yl)oxalamide

There total 9 articles about N₁,N₂-bis((1R,2R)-2-hydroxy-7-phenyl-2,3-dihydro-1H-inden-1-yl)oxalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354558-55-6
(1R,2R)-1-amino-7-phenyl-2,3-dihydro-1H-inden-2-ol

: 95-92-1
oxalic acid diethyl ester

: 1354558-57-8
N₁,N₂-bis((1R,2R)-2-hydroxy-7-phenyl-2,3-dihydro-1H-inden-1-yl)oxalamide

Guidance literature:: With acetic acid; In tetrahydrofuran; at 90 ℃; for 16h;
DOI:10.1039/c1ob06780j

Reference yield:

: 7-phenyl-2,3-dihydro-1H-inden-1-one

: 1354558-57-8
N₁,N₂-bis((1R,2R)-2-hydroxy-7-phenyl-2,3-dihydro-1H-inden-1-yl)oxalamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

2.1: Amberlyst 15 / hexane / 3 h / 0 - 20 °C / Reflux

3.1: C₃₈H₄₂ClMnN₂O₄; 4-methylmorpholine N-oxide / dichloromethane / 0.25 h / -78 °C

3.2: -78 °C

4.1: sodium azide; ammonium chloride / ethanol; water / 2 h / Reflux

5.1: palladium 10% on activated carbon; hydrogen / methanol / 0.33 h

6.1: acetic acid / tetrahydrofuran / 16 h / 90 °C

With sodium tetrahydroborate; sodium azide; palladium 10% on activated carbon; C₃₈H₄₂ClMnN₂O₄; hydrogen; ammonium chloride; acetic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water;
DOI:10.1039/c1ob06780j

Reference yield:

: 868374-23-6
3-oxo-2,3-dihydro-1H-inden-4-yl trifluoromethanesulfonate

: 1354558-57-8
N₁,N₂-bis((1R,2R)-2-hydroxy-7-phenyl-2,3-dihydro-1H-inden-1-yl)oxalamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / Inert atmosphere; Reflux

2.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

3.1: Amberlyst 15 / hexane / 3 h / 0 - 20 °C / Reflux

4.1: C₃₈H₄₂ClMnN₂O₄; 4-methylmorpholine N-oxide / dichloromethane / 0.25 h / -78 °C

4.2: -78 °C

5.1: sodium azide; ammonium chloride / ethanol; water / 2 h / Reflux

6.1: palladium 10% on activated carbon; hydrogen / methanol / 0.33 h

7.1: acetic acid / tetrahydrofuran / 16 h / 90 °C

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; palladium 10% on activated carbon; C₃₈H₄₂ClMnN₂O₄; hydrogen; sodium carbonate; ammonium chloride; acetic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water;
DOI:10.1039/c1ob06780j