BOC-Gly-(Cl)Phe-Ser-Pro-βPhabu-Arg(NO2)-OBZL(NO2)

Base Information

Chemical Name:BOC-Gly-(Cl)Phe-Ser-Pro-βPhabu-Arg(NO2)-OBZL(NO2)
CAS No.:90731-62-7
Molecular Formula:C₄₇H₆₀ClN₁₁O₁₄
Molecular Weight:1038.51
Hs Code.:

Synonyms:

Suppliers and Price of BOC-Gly-(Cl)Phe-Ser-Pro-βPhabu-Arg(NO2)-OBZL(NO2)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of BOC-Gly-(Cl)Phe-Ser-Pro-βPhabu-Arg(NO2)-OBZL(NO2)

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of BOC-Gly-(Cl)Phe-Ser-Pro-βPhabu-Arg(NO2)-OBZL(NO2)

There total 7 articles about BOC-Gly-(Cl)Phe-Ser-Pro-βPhabu-Arg(NO2)-OBZL(NO2) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25488-27-1,134235-83-9
threo-L-(2S,3R)-β-methylphenylalanine

: 90731-62-7
BOC-Gly-(Cl)Phe-Ser-Pro-βPhabu-Arg(NO2)-OBZL(NO2)

Guidance literature:: Multi-step reaction with 6 steps

1: 65 percent

2: 1.) N-Methylmorpholine, isobutyl chlorocarbonate; 2.) N-Methylmorpholine, HBr / 1.) THF, -5 deg C, 15 min; 2.) DMF, -20 deg C, 2 h; -5 deg C, 1 d

3: 2.7 N HCl / methanol; diethyl ether / 0.67 h / Ambient temperature

4: 1.) N-Methylmorpholine, isobutyl chlorocarbonate; 2.) N-Methylmorpholine, HBr / 1.) THF, -5 deg C, 15 min; 2.) DMF, -20 deg C, 2 h; -5 deg C, 1 d

5: 0.5 h / Ambient temperature

6: 1.) 6 N HCl, NaNO₂; 2.) NEt₃ / 1.) DMF, H₂O, -10 deg C, 10 min; 2.) DMF, -5 deg C, 1 h; 4 deg C, 20 h

With 4-methyl-morpholine; hydrogenchloride; hydrogen bromide; triethylamine; sodium nitrite; isobutyl chloroformate; In methanol; diethyl ether;

Reference yield:

: 145432-51-5,630424-76-9
(βR)-N-(tert-butoxycarbonyl)-β-methyl-L-phenylalanine

: 90731-62-7
BOC-Gly-(Cl)Phe-Ser-Pro-βPhabu-Arg(NO2)-OBZL(NO2)

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) N-Methylmorpholine, isobutyl chlorocarbonate; 2.) N-Methylmorpholine, HBr / 1.) THF, -5 deg C, 15 min; 2.) DMF, -20 deg C, 2 h; -5 deg C, 1 d

2: 2.7 N HCl / methanol; diethyl ether / 0.67 h / Ambient temperature

3: 1.) N-Methylmorpholine, isobutyl chlorocarbonate; 2.) N-Methylmorpholine, HBr / 1.) THF, -5 deg C, 15 min; 2.) DMF, -20 deg C, 2 h; -5 deg C, 1 d

4: 0.5 h / Ambient temperature

5: 1.) 6 N HCl, NaNO₂; 2.) NEt₃ / 1.) DMF, H₂O, -10 deg C, 10 min; 2.) DMF, -5 deg C, 1 h; 4 deg C, 20 h

With 4-methyl-morpholine; hydrogenchloride; hydrogen bromide; triethylamine; sodium nitrite; isobutyl chloroformate; In methanol; diethyl ether;

Reference yield:

: 90731-58-1
BOC-βPhabu-Arg(NO2)-OBZL(NO2)

: 90731-62-7
BOC-Gly-(Cl)Phe-Ser-Pro-βPhabu-Arg(NO2)-OBZL(NO2)

Guidance literature:: Multi-step reaction with 4 steps

1: 2.7 N HCl / methanol; diethyl ether / 0.67 h / Ambient temperature

2: 1.) N-Methylmorpholine, isobutyl chlorocarbonate; 2.) N-Methylmorpholine, HBr / 1.) THF, -5 deg C, 15 min; 2.) DMF, -20 deg C, 2 h; -5 deg C, 1 d

3: 0.5 h / Ambient temperature

4: 1.) 6 N HCl, NaNO₂; 2.) NEt₃ / 1.) DMF, H₂O, -10 deg C, 10 min; 2.) DMF, -5 deg C, 1 h; 4 deg C, 20 h

With 4-methyl-morpholine; hydrogenchloride; hydrogen bromide; triethylamine; sodium nitrite; isobutyl chloroformate; In methanol; diethyl ether;