[(3R)-2-oxo-4c-(2-oxo-3-pyridin-3-yl-propylsulfanyl)-3r-tritylamino-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid tert-butyl ester

Base Information

• Chemical Name: [(3R)-2-oxo-4c-(2-oxo-3-pyridin-3-yl-propylsulfanyl)-3r-tritylamino-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid tert-butyl ester
• CAS No.: 54326-58-8
• Molecular Formula: C₅₄H₅₀N₃O₄PS
• Molecular Weight: 868.048

Synonyms:

Chemical Property of [(3R)-2-oxo-4c-(2-oxo-3-pyridin-3-yl-propylsulfanyl)-3r-tritylamino-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(3R)-2-oxo-4c-(2-oxo-3-pyridin-3-yl-propylsulfanyl)-3r-tritylamino-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid tert-butyl ester

There total 2 articles about [(3R)-2-oxo-4c-(2-oxo-3-pyridin-3-yl-propylsulfanyl)-3r-tritylamino-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ [(3R)-2-oxo-4c-(2-oxo-3-pyridin-3-yl-propylsulfanyl)-3r-tritylamino-azetidin-1-yl]-(triphenyl-λ5-phosphanylidene)-acetic acid tert-butyl ester (54326-58-8)

Guidance literature:

Azetidin-2-on 9b, 1) Piperidin, 2) Hydrolyse;

DOI:10.1021/jm00218a018

Reference yield:

→ [2-Oxo-4-(2-oxo-3-pyridin-3-yl-propylsulfanyl)-3-(trityl-amino)-azetidin-1-yl]-(triphenyl-λ5-phosphanylidene)-acetic acid tert-butyl ester (54326-58-8)

Guidance literature:

Phosphoran V, Piperidin;

Reference yield:

[(3R)-2-oxo-4c-(2-oxo-3-pyridin-3-yl-propylsulfanyl)-3r-tritylamino-azetidin-1-yl]-(triphenyl-λ5-phosphanylidene)-acetic acid tert-butyl ester (54326-58-8) → (6R)-7t-((Ξ)-3-tert-butoxycarbonylamino-3-(Ξ)-cyclohex-3-enyl-propionylamino)-8-oxo-3-pyridin-3-ylmethyl-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester (54256-73-4)

Guidance literature:

Multi-step reaction with 3 steps

1: dioxane / Heating

2: TsOH / Heating

3: ClCO₂Me, Et₃N, PHCH₂NMe₂

With N,N'-dimethylbenzylamine; toluene-4-sulfonic acid; triethylamine; methyl chloroformate; In 1,4-dioxane;

DOI:10.1021/jm00218a018

Downstream raw materials:

(6R)-8-oxo-3-pyridin-3-ylmethyl-7t-tritylamino-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

(6R)-7t-((R)-2-hydroxy-2-phenyl-acetylamino)-8-oxo-3-pyridin-3-ylmethyl-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

(6R)-7t-((R)-2-tert-butoxycarbonylamino-2-phenyl-acetylamino)-8-oxo-3-pyridin-3-ylmethyl-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

(6R)-7t-((Ξ)-3-tert-butoxycarbonylamino-3-(Ξ)-cyclohex-3-enyl-propionylamino)-8-oxo-3-pyridin-3-ylmethyl-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

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