Technology Process of (2R,3R)-1,2-epoxy-3-heptadecanol
There total 9 articles about (2R,3R)-1,2-epoxy-3-heptadecanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride; potassium hydroxide; p-toluenesulfonyl chloride;
Yield given. Multistep reaction;
1.) pyridine, 2.) MeOH, 3.) MeOH;
- Guidance literature:
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Multi-step reaction with 7 steps
1: 98 percent / imidazole / dimethylformamide / 10 h
2: 99 percent / AD-mixβ, CH3SO2NH2, H2O / 2-methyl-propan-2-ol / 24 h / 0 °C
3: 89 percent / p-TsOH / acetone / 10 h
4: 92 percent / Bu4FN / tetrahydrofuran / 10 h / Ambient temperature
5: pyridine / 1.) ice-bath, 1 h, 2.) RT, 5 h
6: conc. HCl / methanol / 10 h / Ambient temperature
7: KOH / methanol / 1 h / Ambient temperature
With
pyridine; 1H-imidazole; hydrogenchloride; potassium hydroxide; methanesulfonamide; tetrabutyl ammonium fluoride; water; toluene-4-sulfonic acid; 1,4-bis(9-O-dihydroquinidine)phthalazine;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1016/0040-4020(96)00477-2
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 89 percent / p-TsOH / acetone / 10 h
2: 92 percent / Bu4FN / tetrahydrofuran / 10 h / Ambient temperature
3: pyridine / 1.) ice-bath, 1 h, 2.) RT, 5 h
4: conc. HCl / methanol / 10 h / Ambient temperature
5: KOH / methanol / 1 h / Ambient temperature
With
pyridine; hydrogenchloride; potassium hydroxide; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; acetone;
DOI:10.1016/0040-4020(96)00477-2
