2-Phenylthiomethyl-3-carboxy-5-hydroxybenzofuran

Base Information

• Chemical Name: 2-Phenylthiomethyl-3-carboxy-5-hydroxybenzofuran
• CAS No.: 100095-74-7
• Molecular Formula: C₁₆H₁₂O₄S
• Molecular Weight: 300.335
• Mol file: 100095-74-7.mol

Synonyms:

Chemical Property of 2-Phenylthiomethyl-3-carboxy-5-hydroxybenzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Phenylthiomethyl-3-carboxy-5-hydroxybenzofuran

There total 1 articles about 2-Phenylthiomethyl-3-carboxy-5-hydroxybenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

3-ethoxycarbonyl-5-hydroxy-2-phenylthiomethylbenzofuran (100095-73-6) → 2-Phenylthiomethyl-3-carboxy-5-hydroxybenzofuran (100095-74-7)

Guidance literature:

With potassium hydroxide; for 2h; Heating;

DOI:10.1007/BF00833355

Reference yield: 24.3%

2-Phenylthiomethyl-3-carboxy-5-hydroxybenzofuran (100095-74-7) + dimethyl sulfate (77-78-1) → 2-phenylthiomethyl-3-hydroxycarbonyl-5-methoxybenzofuran (100095-75-8)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; Heating;

DOI:10.1007/BF00833355

Reference yield:

2-Phenylthiomethyl-3-carboxy-5-hydroxybenzofuran (100095-74-7) → 2-Chloromethyl-3-carboxy-5-methoxybenzofuran anilide (100095-81-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 24.3 percent / NaOH / dioxane; H₂O / Heating

2: SOCl₂ / dioxane / 1.) reflux, 2 h, 2.) 20 deg C, overnight

3: 68.3 percent / diethyl ether / 24 h

4: 83.8 percent / NaIO₄ / methanol; H₂O / 1 h / Heating

5: 56.7 percent / SOCl₂ / CH₂Cl₂ / 2.5 h / Heating

With sodium hydroxide; sodium periodate; thionyl chloride; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; water;

DOI:10.1007/BF00833355

upstream raw materials:

3-ethoxycarbonyl-5-hydroxy-2-phenylthiomethylbenzofuran

Downstream raw materials:

2-phenylthiomethyl-3-hydroxycarbonyl-5-methoxybenzofuran

2-Chloromethyl-3-carboxy-5-methoxybenzofuran anilide

2-Phenylthiomethyl-3-carboxy-5-methoxybenzofuran anilide

2-Phenylsulfinylmethyl-3-carboxy-5-methoxybenzofuran anilide

Refernces