N-[4-(hydroxymethyl)-3-methylphenyl]acetamide

Base Information

• Chemical Name: N-[4-(hydroxymethyl)-3-methylphenyl]acetamide
• CAS No.: 117523-91-8
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• European Community (EC) Number: 601-481-5
• DSSTox Substance ID: DTXSID30708688
• Mol file: 117523-91-8.mol

Synonyms:N-[4-(hydroxymethyl)-3-methylphenyl]acetamide;117523-91-8;4-acetamido-2-methylbenzyl alcohol;SCHEMBL377420;DTXSID30708688;LUGUYMHBKVWFQP-UHFFFAOYSA-N;N-[4-(Hydroxymethyl)-3-methyl phenyl]acetamide

Chemical Property of N-[4-(hydroxymethyl)-3-methylphenyl]acetamide

Chemical Property:

• Vapor Pressure: 7.55E-07mmHg at 25°C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 179.094628657
• Heavy Atom Count: 13
• Complexity: 182

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=C1)NC(=O)C)CO

Technology Process of N-[4-(hydroxymethyl)-3-methylphenyl]acetamide

There total 2 articles about N-[4-(hydroxymethyl)-3-methylphenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-acetylamino-2-methylbenzoic acid (103204-69-9) → N-[4-(hydroxymethyl)-3-methylphenyl]acetamide (117523-91-8)

Guidance literature:

4-acetylamino-2-methylbenzoic acid; With borane-THF; In tetrahydrofuran; at 20 ℃;

With water; In tetrahydrofuran;

Reference yield:

4-acetamido-2-methyl benzaldehyde (84257-50-1) → N-[4-(hydroxymethyl)-3-methylphenyl]acetamide (117523-91-8)

Guidance literature:

With sodium borohydrid; In methanol;

Reference yield:

N-[4-(hydroxymethyl)-3-methylphenyl]acetamide (117523-91-8) → 4-acetamido-2-methyl benzaldehyde (84257-50-1)

Guidance literature:

With manganese(IV) oxide; In acetonitrile; at 120 ℃; for 0.116667h; Microwave irradiation;

upstream raw materials:

4-acetylamino-2-methylbenzoic acid

4-acetamido-2-methyl benzaldehyde

Downstream raw materials:

4-acetamido-2-methyl benzaldehyde

4-(acetylamino)-2-methylphenyl acetate