3-(2-oxopiperidin-1-yl)propanoic acid

Base Information

• Chemical Name: 3-(2-oxopiperidin-1-yl)propanoic acid
• CAS No.: 117705-04-1
• Molecular Formula: C8H13NO3
• Molecular Weight: 171.196
• Hs Code.: 2933790090
• Mol file: 117705-04-1.mol

Synonyms:1-Piperidinepropanoic acid,2-oxo;

Chemical Property of 3-(2-oxopiperidin-1-yl)propanoic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 380.783oC at 760 mmHg
• Flash Point: 184.091oC
• PSA: 57.61000
• Density: 1.199g/cm3
• LogP: 0.41150
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-(2-Oxopiperidin-1-yl)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-oxopiperidin-1-yl)propanoic acid

There total 6 articles about 3-(2-oxopiperidin-1-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethyl piperidine-1-propionate (19653-33-9) → 3-(2-oxopiperidin-1-yl)propionic acid (117705-04-1)

Guidance literature:

With water; oxygen; sodium hydroxide; In 1,4-dioxane; at 80 ℃; for 24h; under 760.051 Torr; regioselective reaction; Green chemistry;

DOI:10.1002/anie.201602695

Reference yield: 59.0%

3-(2-oxo-1-piperidinyl)propanal (138196-45-9) → 3-(2-oxopiperidin-1-yl)propionic acid (117705-04-1)

Guidance literature:

With sodium hydroxide; silver nitrate; at 0 ℃; for 0.0833333h;

Reference yield:

N-(3-(tetrahydropyranyloxy)propyl)valerolactam (76243-33-9) → 3-(2-oxopiperidin-1-yl)propionic acid (117705-04-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / Amberlyst-15 / methanol / 6 h / 45 °C

2: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 15 min, 2.) CH₂Cl₂, -60 deg C, 5 min

3: 59 percent / AgNO₃, aq. NaOH / 0.08 h / 0 °C

With sodium hydroxide; amberlyst-15; oxalyl dichloride; silver nitrate; dimethyl sulfoxide; triethylamine; In methanol;

upstream raw materials:

3-[2-oxopyridin-1(2H)-yl]propanoic acid

3-(2-oxo-1-piperidinyl)propanal

1-(3'-hydroxypropyl)piperidin-2-one

N-(3-(tetrahydropyranyloxy)propyl)valerolactam

Downstream raw materials:

methyl 3-(2-oxopiperidino)propionate

3-(2,6-dichloro-phenyl)-5-[2-(2-oxo-piperidin-1-yl)-ethyl]-isoxazole-4-carboxylic acid ethyl ester

3-(2,6-dichloro-phenyl)-5-[2-(2-oxo-piperidin-1-yl)-ethyl]-isoxazole-4-carboxylic acid

N-carboxyethyl-γ-aminobutyric acid

Refernces

• 1、 Jin, Xiongjie,Kataoka, Kengo,Yatabe, Takafumi,Yamaguchi, Kazuya,Mizuno, Noritaka. "Supported Gold Nanoparticles for Efficient α-Oxygenation of Secondary and Tertiary Amines into Amides". supporting information. p. 7212 - 7217. Retrieved 2016/07/06.
• 2、 -. "Pyrrole derivatives, their preparation and pharmaceutical compositions which contain them". . . Retrieved 2008/06/13.